89095
(R)-Tetrahydrofurfuryl alcohol
≥98.0% (sum of enantiomers, GC)
Synonym(s):
(R)-Tetrahydrofuran-2-methanol
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About This Item
Empirical Formula (Hill Notation):
C5H10O2
CAS Number:
Molecular Weight:
102.13
Beilstein:
79846
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.22
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Assay
≥98.0% (sum of enantiomers, GC)
form
liquid
optical purity
enantiomeric ratio: ≥97:3% (GC)
bp
178 °C (lit.)
density
1.054 g/mL at 20 °C (lit.)
functional group
ether
hydroxyl
SMILES string
OC[C@H]1CCCO1
InChI
1S/C5H10O2/c6-4-5-2-1-3-7-5/h5-6H,1-4H2/t5-/m1/s1
InChI key
BSYVTEYKTMYBMK-RXMQYKEDSA-N
Application
(R)-Tetrahydrofurfuryl alcohol can be used:
- To prepare (R)-tetrahydrofurfuryl aldehyde, which is employed as a building block to synthesize a fragment of pectenotoxin-4.
- As a starting material to synthesize naftidrofuryl isomers, used as potent 5-hydroxytryptamine 2A receptor antagonists.
- As a building block for the preparation of (S)-2-tetrahydrofuran methyl ether 6-fluorophenyl ether analog, as an IGF-1R inhibitor.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Rhodium-catalysed vinyl 1, 4-conjugate addition coupled with Sharpless asymmetric dihydroxylation in the synthesis of the CDE ring fragment of pectenotoxin-4
Richardson MSW, et al.
Chemical Science, 10(25), 6336-6340 (2019)
Practical access to four stereoisomers of naftidrofuryl and their binding affinity towards 5-hydroxytryptamine 2A receptor
Hao J, et al.
Bioorganic & Medicinal Chemistry Letters, 22(10), 3441-3444 (2012)
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors
Fairhurst RA, et al.
Bioorganic & medicinal chemistry letters, 26(8), 2057-2064 (2016)
[Acute poisoning with tetrahydrofurfuryl alcohol combined with methanol].
B F Murashov et al.
Voenno-meditsinskii zhurnal, (10)(10), 32-34 (1983-10-01)
G Zarnt et al.
Applied and environmental microbiology, 63(12), 4891-4898 (1997-12-24)
An organism tentatively identified as Ralstonia eutropha was isolated from enrichment cultures containing tetrahydrofurfuryl alcohol (THFA) as the sole source of carbon and energy. The strain was able to tolerate up to 200 mM THFA in mineral salt medium. The
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