860832
2-Thiocytidine dihydrate
98%
SMILES string
NC1=NC(=S)N(C=C1)[C@H]2O[C@H](CO)[C@@H](O)[C@H]2O
assay
98%
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L Wang et al.
Nucleic acids research, 25(21), 4355-4361 (1997-10-23)
The hammerhead domain is one of the smallest known ribozymes. Like other ribozymes it catalyzes site-specific cleavage of a phosphodiester bond. The hammerhead ribozyme has been the subject of a vast number of biochemical and structural studies aimed at determining
D J Earnshaw et al.
Biochemistry, 39(21), 6410-6421 (2000-06-01)
The hairpin ribozyme achieves catalytic cleavage through interaction of essential nucleotides located in two distinct helical domains that include internal loops. Initial docking of the two domains is ion dependent and appears to be followed by a structural rearrangement that
Akihiro Ohkubo et al.
Organic & biomolecular chemistry, 10(10), 2008-2010 (2012-01-28)
In this paper, we report DNA and 2'-OMe-RNA probes containing 5-methyl-2-thiocytidine (m(5)s(2)C) residues that can bind selectively and strongly to the corresponding RNA targets containing inosine residues by the significant stacking effect and steric hindrance of the 2-thiocarbonyl group.
G Ott et al.
European journal of biochemistry, 184(2), 345-352 (1989-09-15)
Transfer ribonucleic acids containing 2-thiocytidine in position 75 ([s2C]tRNAs) were prepared by incorporation of the corresponding cytidine analogue into 3'-shortened tRNA using ATP(CTP):tRNA nucleotidyltransferase. [s2C]tRNA was selectively alkylated with fluorescent N-iodoacetyl-N'-(5-sulfo-1-naphthyl)ethylenediamine (1,5-I-AEDANS) on the 2-thiocytidine residue. The product [AEDANS-s2C]aminoacyl-tRNA, forms
Hans K Lundgren et al.
Journal of bacteriology, 188(8), 3052-3062 (2006-04-06)
The cysteine desulfurase IscS in Salmonella enterica serovar Typhimurium is required for the formation of all four thiolated nucleosides in tRNA, which is thought to occur via two principally different biosynthetic pathways. The synthesis of 4-thiouridine (s(4)U) and 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U)
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