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About This Item
Empirical Formula (Hill Notation):
C11H11NO2
CAS Number:
Molecular Weight:
189.21
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Assay
99%
form
solid
mp
83-85 °C (lit.)
SMILES string
CC1(CC(=O)NC1=O)c2ccccc2
InChI
1S/C11H11NO2/c1-11(7-9(13)12-10(11)14)8-5-3-2-4-6-8/h2-6H,7H2,1H3,(H,12,13,14)
InChI key
UDESUGJZUFALAM-UHFFFAOYSA-N
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
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Arcadius V Krivoshein
ACS chemical neuroscience, 7(3), 316-326 (2016-01-08)
Although the antiepileptic properties of α-substituted lactams, acetamides, and cyclic imides have been known for over 60 years, the mechanism by which they act remains unclear. I report here that these compounds bind to the nicotinic acetylcholine receptor (nAChR) and
J C Gomora et al.
Molecular pharmacology, 60(5), 1121-1132 (2001-10-20)
Inhibition of T-type Ca(2+) channels has been proposed to play a role in the therapeutic action of succinimide antiepileptic drugs. Despite the widespread acceptance of this hypothesis, recent studies using rat and cat neurons have failed to confirm inhibition of
M B Tennison et al.
Pediatrics, 87(2), 186-189 (1991-02-01)
Methsuximide was added to the therapeutic regimens of 25 children with intractable epilepsy. In 15 patients the drug was well tolerated and resulted in a 50% or greater reduction in seizure frequency. No serious or irreversible adverse effects were seen.
G K Szabo et al.
Clinical chemistry, 28(1), 100-104 (1982-01-01)
We describe an improved "high-pressure" liquid-chromatographic assay for simultaneous determination in serum of the five major antiepileptic drugs (ethosuximide, primidone, phenobarbital, phenytoin, and carbamazepine) and N-desmethylmethsuximide (the compound that must be quantitated for therapeutic drug monitoring of the antiepileptic drug
Pharmacokinetics of N-desmethylmethsuximide in pediatric patients.
M V Miles et al.
The Journal of pediatrics, 114(4 Pt 1), 647-650 (1989-04-01)
Chromatograms
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