852597
5-Iodouridine
95%
Synonym(s):
2,4-Dihydroxy-5-iodo-1-β-D-ribofuranosylpyrimidine
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About This Item
Empirical Formula (Hill Notation):
C9H11IN2O6
CAS Number:
Molecular Weight:
370.10
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
213-833-1
Beilstein/REAXYS Number:
33665
MDL number:
Assay:
95%
Form:
powder
InChI key
RKSLVDIXBGWPIS-UAKXSSHOSA-N
InChI
1S/C9H11IN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1
SMILES string
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=C(I)C(=O)NC2=O
assay
95%
form
powder
mp
205-207 °C (dec.) (lit.)
functional group
ether, hydroxyl, iodo
storage temp.
2-8°C
Quality Level
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Dehalogenation reactions in fast atom bombardment mass spectrometry.
S K Sethi et al.
Analytical chemistry, 56(11), 1975-1977 (1984-09-01)
Daniel E Ryan et al.
RNA (New York, N.Y.), 10(8), 1251-1265 (2004-07-24)
Elucidation of the three-dimensional (3D) structures of the two sequential active sites in spliceosomes is essential for understanding the mechanism of premessenger RNA splicing. The mechanism is predicted to be catalyzed by the small nuclear RNA (snRNA) components of spliceosomes.
W T Stump et al.
RNA (New York, N.Y.), 1(1), 55-63 (1995-03-01)
The N-terminal RNA binding domain (RBD) of the human U1A snRNP protein binds tightly and specifically to an RNA hairpin that contains a 10-nucleotide loop. The protein is one of a class of RNA binding proteins that adopts a beta
B L Golden et al.
RNA (New York, N.Y.), 2(12), 1295-1305 (1996-12-01)
For small RNAs, isomorphous heavy-atom derivatives can be obtained by crystallizing synthetic versions that incorporate modified nucleotides such as iodo- or bromouridine. However, such a synthetic approach is not yet feasible for RNAs greater than approximately 40 nt. We have
Loïc Ropartz et al.
Chemical communications (Cambridge, England), (15)(15), 1556-1558 (2007-04-05)
Novel transition metal catalysts based on oligonucleotides can be easily obtained by functionalization of 5-iodouridine with phosphine ligands, resulting in good asymmetric induction in palladium catalyzed allylic nucleophilic substitution.
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