802107
Poly(N-isopropyl acrylamide), amine terminated
end functionalized by RAFT, PDI ≤1.3, Mn 5,000
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Synonym(s):
NIPAM polymer, PNIPAM-NH2, functionalized polyNIPAM, functionalized polyacrylamide, polyacrylamide
Linear Formula:
H(C6H11NO)n(CH2)NH2
UNSPSC Code:
12162002
NACRES:
NA.23
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form
powder
mol wt
Mn 5,000
PDI
≤1.3
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Application
Novel polymer for development of thermosensitive coated micro/nano materials including thermoresponsive polymeric drug delivery systems. The amine functinal group can be used to attach a variety of biomolecules to the polymer chain.
Legal Information
Sold for research purposes only: See sigma-aldrich.com/raftlicense. Patents: WO98/01478, WO99/311444.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Reversibly thermo-responsive alkyl-terminated poly(N-isopropylacrylamide) core-shell micellar structures.
Chung JE, et al.
Colloids and Surfaces. B, Biointerfaces, 9(1-2), 37-48 (1997)
Hua Wei et al.
Biomaterials, 28(1), 99-107 (2006-09-09)
A four-arm star block copolymer, comprised of a hydrophobic PMMA arm and an average of three hydrophilic poly(N-isopropylacrylamide) (PNIPAAm) arms were designed and synthesized from the molecular level. The amphiphilic star block copolymer is capable of self-assembling into micelles in
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