79625
N,N-Dimethylphosphoramic dichloride
≥98.0% (AT)
Synonym(s):
DMPADC, Dimethylamidophosphoric dichloride
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About This Item
Linear Formula:
(CH3)2NP(O)Cl2
CAS Number:
Molecular Weight:
161.95
Beilstein:
969956
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Quality Level
Assay
≥98.0% (AT)
form
liquid
refractive index
n20/D 1.464
bp
77-79 °C/11 mmHg (lit.)
density
1.362 g/mL at 20 °C (lit.)
storage temp.
2-8°C
SMILES string
CN(C)P(Cl)(Cl)=O
InChI
1S/C2H6Cl2NOP/c1-5(2)7(3,4)6/h1-2H3
InChI key
YNHXBEVSSILHPI-UHFFFAOYSA-N
Related Categories
Application
N,N-Dimethylphosphoramic dichloride can be used as a reagent:
- For the activation of carboxylic acids.
- To prepare functionalized β-lactams by reacting with acetic acids and imines.
- To synthesize phosphoramidic esters by reacting with alcohols in the presence of a base catalyst.
- To prepare [1,2,4]triazolo[4,3-c][1,3,5,2]triazaphosphinine-5-oxide derivatives by reacting with N-alkyl/aryl-N′-(4H-1,2,4-triazol-3-yl) amidines in the presence of triethylamine.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Skin Corr. 1B
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
监管及禁止进口产品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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A solid supported, rapid and mild synthesis of CWC related phosphoramidates
Shakya P, et al.
Catalysis Communications, 6, 669-673 (2005)
H.J. Liu et al.
Tetrahedron Letters, 4461-4461 (1978)
Convenient procedures for esterification of carboxylic acids
Hsing-Jang L, et al.
Tetrahedron Letters, 19, 4461-4464 (1978)
F.P. Cossio et al.
Tetrahedron Letters, 28, 1945-1945 (1987)
A new route to [1, 2, 4] triazolo [4, 3-c][1, 3, 5, 2] triazaphosphinine-5-oxides: reactivity of N-alkyl/aryl-n'-(4h-1, 2, 4-triazol-3-yl) amidines with N, N-dimethylphosphoramic dichloride
Hajr A and Marzouki L
Bulletin of the Chemical Society of Ethiopia, 34, 157-161 (2020)
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