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779660

Sigma-Aldrich

γ-Cyclodextrin

Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, 98.3-102.0% cyclodextrin basis

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Synonym(s):
Cavamax® W8, Cyclomaltooctaose, Cyclooctaamylose, Schardinger γ-Dextrin
Empirical Formula (Hill Notation):
C48H80O40
CAS Number:
17465-86-0
Molecular Weight:
1297.12
Beilstein:
78740
EC Number:
241-482-4
MDL number:
MFCD00009595
UNSPSC Code:
12352005
PubChem Substance ID:
329768057
NACRES:
NA.22

grade

Produced by Wacker Chemie AG, Burghausen, Germany, Life Science

Quality Level

100

Assay

98.3-102.0% cyclodextrin basis

form

crystals

optical activity

[α]/D 174.0 to 180.0°

impurities

≤0.20% reducing substances
≤0.5% related substances (sum)
≤0.50% impurities A, B and C (related substances) (single)
≤5 ppm heavy metals
≤8 ppm volatile organics

ign. residue

≤0.10%

loss

≤11.0% loss on drying

λ

10 % in H2O

UV absorption

λ: 420 nm Amax: ≤0.20

SMILES string

[H][C@]1(O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@@H]2[C@@H](COC(C)=O)O[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O

InChI

1S/C48H80O40/c49-1-9-33-17(57)25(65)41(73-9)82-34-10(2-50)75-43(27(67)19(34)59)84-36-12(4-52)77-45(29(69)21(36)61)86-38-14(6-54)79-47(31(71)23(38)63)88-40-16(8-56)80-48(32(72)24(40)64)87-39-15(7-55)78-46(30(70)22(39)62)85-37-13(5-53)76-44(28(68)20(37)60)83-35-11(3-51)74-42(81-33)26(66)18(35)58/h9-72H,1-8H2/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m1/s1

InChI key

GDSRMADSINPKSL-HSEONFRVSA-N

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Application

γ-Cyclodextrin (γ-CD), a water-soluble cyclic oligosaccharide consisting of eight α-(1,4)-linked glucopyranose subunits, can be used in a wide range of applications including:
  • Synthesis of renewable and biocompatible metal-organic frameworks.
  • Formation of inclusion complexes with a variety of guest molecules to increase their solubility in water and other polar solvents.
  • Synthesis of γ-CD based nanogels and dendrimers as carriers and stabilizers for drug delivery applications.

Legal Information

Cavamax is a registered trademark of Wacker Chemie AG

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cyclodextrin-mediated enhancement of riboflavin solubility and corneal permeability.
Morrison, Peter WJ et al.
Molecular Pharmaceutics, 10(2), 756-762 (2013)
Cross-linked hydroxypropyl-β-cyclodextrin and γ-cyclodextrin nanogels for drug delivery: physicochemical and loading/release properties.
Moya-Ortega, Maria D et al.
Carbohydrate Polymers, 87(3), 2344-2351 (2012)
Metal-organic frameworks from edible natural products.
Smaldone, Ronald A et al.
Angewandte Chemie (International Edition in English), 49(46), 8630-8634 (2010)
γ-Cyclodextrin: a review on enzymatic production and applications.
Li, Zhaofeng et al.
Applied Microbiology and Biotechnology, 77(2), 245-245 (2007)
Cyclodextrin functionalized graphene nanosheets with high supramolecular recognition capability: synthesis and host- guest inclusion for enhanced electrochemical performance.
Guo, Yujing et al.
ACS Nano, 4(7), 4001-4010 (2010)
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