76763
1-(4-Pyridyl)piperazine
≥97.0% (GC)
Synonym(s):
4-Piperazinopyridine
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About This Item
Empirical Formula (Hill Notation):
C9H13N3
CAS Number:
Molecular Weight:
163.22
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
213-764-7
MDL number:
Assay:
≥97.0% (GC)
Form:
powder
InChI
1S/C9H13N3/c1-3-10-4-2-9(1)12-7-5-11-6-8-12/h1-4,11H,5-8H2
InChI key
OQZBAQXTXNIPRA-UHFFFAOYSA-N
SMILES string
C1CN(CCN1)c2ccncc2
assay
≥97.0% (GC)
form
powder
impurities
≤1% water
mp
137-141 °C
Quality Level
Gene Information
rat ... Chrnb2(54239)
Related Categories
General description
1-(4-Pyridyl) piperazine (or 4-Piperazinopyridine) is an active structural component that is used as a building block to prepare various medicinally important active molecules.
Application
1-(4-Pyridyl) piperazine can be used as a building block for the synthesis of:
- Nocathiacin I analogs for antibacterial studies.
- 4-amino-pyridyl derivatives, benzimido isoquinoline based derivatives and tert-pentylphenoxyalkyl piperazine derivatives for various biological applications.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Regulatory Information
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N ε-Acryloyllysine Piperazides as Irreversible Inhibitors of Transglutaminase 2: Synthesis, Structure?Activity Relationships, and Pharmacokinetic Profiling.
Wodtke R, et al.
Journal of Medicinal Chemistry, 61(10), 4528-4560 (2018)
Polymethacrylates containing a 4-amino-pyridyl derivative covalently attached as effective catalysts in acylation chemistry: self-activation by neighboring group effects
Mennenga T, et al.
Polymer International, 64(12), 1685-1689 (2015)
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl) piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl) amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
Swanson D M, et al.
Journal of Medicinal Chemistry, 48(6), 1857-1872 (2005)
Nocathiacin I analogues: synthesis, in vitro and in vivo biological activity of novel semi-synthetic thiazolyl peptide antibiotics
Naidu BN, et al.
Bioorganic & Medicinal Chemistry, 14(22), 5573-5577 (2004)
Identification of ML204: a novel potent antagonist that selectively modulates native TRPC4/C5 channels.
Miller M, et al.
The Journal of Biological Chemistry, jbc-M111 (2011)
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