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765376

Sigma-Aldrich

Gold nanoparticles

30 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H2O

Synonym(s):

Gold nanoparticles NH2 functionalized, Au NP NH2, Gold Colloid

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25 G
¥2,465.37
500 G
¥10,505.95

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Available to ship on2025年4月27日Details

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25 G
¥2,465.37
500 G
¥10,505.95

About This Item

UNSPSC Code:
12162002
NACRES:
NA.23

¥2,465.37

Available to ship on2025年4月27日Details

Request a Bulk Order

material

PEG 5000

Quality Level

100

form

dispersion in H2O
nanoparticles

packaging

poly bottle of 1 mL

OD

50

diameter

30 nm

pH

6.0-8.0 (25 °C)

solubility

water: miscible

density

1.00 g/cm3

λmax

525 nm

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1 of 4

This Item
D15292780352513259
Dimethyl carbonate battery grade, ≥99.9%, acid <10 ppm, H2O <10 ppm

809942

Dimethyl carbonate

Dimethyl carbonate ReagentPlus®, 99%

D152927

Dimethyl carbonate

Dimethyl carbonate for synthesis

803525

Dimethyl carbonate

Dimethyl carbonate analytical standard

13259

Dimethyl carbonate

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

grade

battery grade

grade

-

grade

-

grade

analytical standard

form

liquid

form

liquid

form

liquid

form

-

application(s)

battery manufacturing

application(s)

-

application(s)

-

application(s)

environmental
pharmaceutical

impurities

≤10 ppm H2O, ≤10 ppm acid

impurities

-

impurities

-

impurities

≤0.02% water

assay

≥99.9%

assay

99%

assay

≥99.0% (GC)

assay

≥99.0% (GC)

General description

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. Amine functionalized GNPs which have Poly Ethylene Glycol (PEG) as the ligand or carrier molecule forms a conjugate with siRNA and is extremely useful in RNAi technology. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.[1][2][3][4]

Application

Functionalized particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
Several other specific applications have been listed below:
  • Since they adhere to cell membranes, AuNPs are used in cellular and intracellular targeting in targeted drug delivery applications and can also be used in biodistribution studies
  • AuNPs may also be used in photothermal therapy and radiotherapy.
  • Proposed applications of gold nanoparticles are as:drug delivery agents for cancer therapy, coatings, plastics, nanowire, nanofiber, textiles, catalyst applications.
  • They may also be used in carrying siRNA which acts against human prostate carcinoma cells by inhibiting a specific cancer gene.[5][4]

Features and Benefits

  • A Negatively charged siRNA-PEG complex attached to positively charged GNPs is easily cleavable in reductive cytosolic environment thus enabling the release of siRNA into cytosol.[5][4]
  • The PEG coating decreases the cytotoxicity and increases efficiency of GNPs. PEG increases the stability of the nanoparticles and prevents agglomeration.[1]

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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    Certificates of Analysis (COA)

    Lot/Batch Number
    MKBX4831V
    MKBN9286V

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    Sarah D Brown et al.
    Journal of the American Chemical Society, 132(13), 4678-4684 (2010-03-17)
    The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are an important component of chemotherapy but are limited by severe dose-limiting side effects and the ability of tumors to develop resistance rapidly. These drugs can be improved through the use of
    Scott H Brewer et al.
    Langmuir : the ACS journal of surfaces and colloids, 21(20), 9303-9307 (2005-09-21)
    The interaction of bovine serum albumin (BSA) with gold colloids and surfaces was studied using zeta-potential and quartz crystal microbalance (QCM) measurements, respectively, to determine the surface charge and coverage. The combination of these two measurements suggests that BSA binding
    Timothy A Larson et al.
    ACS nano, 6(10), 9182-9190 (2012-09-27)
    Polyethylene glycol (PEG) surface coatings are widely used to render stealth properties to nanoparticles in biological applications. There is abundant literature on the benefits of PEG coatings and their ability to reduce protein adsorption, to diminish nonspecific interactions with cells
    Xiao-Dong Zhang et al.
    International journal of nanomedicine, 6, 2071-2081 (2011-10-07)
    Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of
    Functionalized gold nanoparticles and their biomedical applications
    Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.
    Nanomaterials, 1(1), 31-63 (2011)

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    Biomaterials science integrates smart materials into biological research, requiring a deep understanding of biological systems.

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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