All Photos(1)
Synonym(s):
Acetylene-PEG5-NHS ester, Alkyne-PEG5-NHS ester, Alkyne-PEG5-succinimidyl ester
Empirical Formula (Hill Notation):
C18H27NO9
Molecular Weight:
401.41
MDL number:
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
form
liquid
Quality Level
reaction suitability
reaction type: click chemistry
reagent type: cross-linking reagent
functional group
NHS ester
alkyne
storage temp.
−20°C
SMILES string
C#CCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O
InChI
1S/C18H27NO9/c1-2-6-23-8-10-25-12-14-27-15-13-26-11-9-24-7-5-18(22)28-19-16(20)3-4-17(19)21/h1H,3-15H2
InChI key
ACZDUKRWTPZVRP-UHFFFAOYSA-N
Related Categories
Application
Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a primary amine. The succinimidyl ester group will react preferentially with primary amines to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification amine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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