Skip to Content
Merck
CN
All Photos(1)

Documents

Safety Information

762334

Sigma-Aldrich

Diethyl methylphosphonite

97%

Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
Diethoxymethylphosphine
Empirical Formula (Hill Notation):
C5H13O2P
CAS Number:
15715-41-0
Molecular Weight:
136.13
EC Number:
239-805-9
MDL number:
MFCD00009089
UNSPSC Code:
12352108
PubChem Substance ID:
329766965
NACRES:
NA.22

Quality Level

100

Assay

97%

form

liquid

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand

refractive index

n20/D 1.419

density

0.907 g/mL at 25 °C

storage temp.

2-8°C

SMILES string

CCOP(C)OCC

InChI

1S/C5H13O2P/c1-4-6-8(3)7-5-2/h4-5H2,1-3H3

InChI key

NSSMTQDEWVTEKN-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

Diethyl methylphosphonite can be used as a mild reducing reagent in the oxalimide cyclization of oxalylazetidinonyl thiocarbonates and thioesters. It can also be used in the synthesis of β-carboxamido-phosphon(in)ic acids as potential inhibitors of human mast cell chymase.

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Warning

Hazard Statements

H226,H302

Precautionary Statements

P210 - P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral - Flam. Liq. 3

WGK

WGK 3

Flash Point(F)

84.9 °F

Flash Point(C)

29.4 °C

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Alkylphosphonous acid diesters, novel reagents for the oxalimide cyclization to penems.
Budt K H, et al.
Tetrahedron Letters, 33(37), 5331-5334 (1992)
Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase.
Greco M N, et al.
Journal of Medicinal Chemistry, 50(8), 1727-1730 (2007)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service