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740500

Sigma-Aldrich

Chitosan

high purity, Mv 110,000-150,000

Synonym(s):

KiOmedine-CsU® C, Deacetylated chitin, Poly(D-glucosamine)

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About This Item

CAS Number:
9012-76-4
MDL number:
MFCD00161512
UNSPSC Code:
12352201

biological source

white mushroom

grade

high purity

form

powder

mol wt

Mv 110,000-150,000

composition

Bacterial endotoxins, ≤10 EU/g
Beta-glucan, ≤5 % (w/w)
Chitosan, ≥93 % (w/w)
Proteins, ≤1 % (w/w)

viscosity

5-200 mPa.s (1% solution in 1% HAc)

solubility

acetic acid: 1% (solution)

storage temp.

2-8°C

InChI

1S/C56H103N9O39/c1-87-56(86)65-28-38(84)46(19(10-74)96-55(28)104-45-18(9-73)95-49(27(64)37(45)83)97-39-12(3-67)88-47(85)20(57)31(39)77)103-54-26(63)36(82)44(17(8-72)94-54)102-53-25(62)35(81)43(16(7-71)93-53)101-52-24(61)34(80)42(15(6-70)92-52)100-51-23(60)33(79)41(14(5-69)91-51)99-50-22(59)32(78)40(13(4-68)90-50)98-48-21(58)30(76)29(75)11(2-66)89-48/h11-55,66-85H,2-10,57-64H2,1H3,(H,65,86)/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48+,49+,50+,51+,52+,53+,54+,55+/m1/s1

InChI key

FLASNYPZGWUPSU-SICDJOISSA-N

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General description

KiOmedine-CSU® is an ultra-pure chitosan of non-animal origin, produced from white mushrooms (Agaricus bisporus), in accordance with cGMP.
The crystalline structure is in the alpha form. The linkage between glucosamine units is beta(1,4).

Application

Forms gels with multivalent anions. Gives clear solutions that dry to strong, clear films.
Ideal for wound healing and hemostasis; biosurgery and ophthalmology, scaffold and cell therapy; and drug delivery and vaccines

Features and Benefits

Biocompatible, antibacterial and environmentally friendly polyelectrolyte with a variety of applications including water treatment, chromatography, additives for cosmetics, textile treatment for antimicrobial activity, novel fibers for textiles, photographic papers, biodegradable films, biomedical devices, and microcapsule implants for controlled release in drug delivery.

Physical properties

Degree of acetylation: ≤40 mol. %

Legal Information

Product of KitoZyme
KiOmedine is a registered trademark of KitoZyme, S.A.

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Liming Hu et al.
Nanoscale, 5(8), 3103-3111 (2013-03-22)
Within the past few years, chitosan-based drug delivery vehicles have become some of the most attractive to be studied. In contrast to all other polysaccharides, chitosan has demonstrated its unique characteristics for drug delivery platforms, including its active primary amino
Abdelkrim El Kadib et al.
Journal of nanoscience and nanotechnology, 14(1), 308-331 (2014-04-16)
Polysaccharides are a new class of pervasive biopolymers that display many advantages including wide availability, sustainability, inherent inclusion of chemical functionality, biocompatibility and biodegradability. Current efforts are focused on the catalytic transformation of these macromolecules into fuels and platform chemicals.
Alberto Busilacchi et al.
Carbohydrate polymers, 98(1), 665-676 (2013-08-31)
The idea of using chitosan as a functional delivery aid to support simultaneously PRP, stem cells and growth factors (GF) is associated with the intention to use morphogenic biomaterials to modulate the natural healing sequence in bone and other tissues.
Stephanie Supper et al.
Expert opinion on drug delivery, 11(2), 249-267 (2013-12-07)
Thermogelling chitosan (CS)/glycerophosphate (GP) solutions have been reported as a new type of parenteral in situ forming depot system. These free-flowing solutions at ambient temperature turn into semi-solid hydrogels after parenteral administration. Formulation parameters such as CS physico-chemical characteristics, CS/gelling
Hajer Aloui et al.
International journal of food microbiology, 170, 21-28 (2013-12-03)
This study reports the efficacy of the combined application of chitosan (CH) and Locust Bean Gum (LBG) in combination with different citrus essential oils (EOs) to inhibit Aspergillus flavus in vitro and on artificially infected dates for a storage period
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