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724823

Sigma-Aldrich

Poly(N-isopropylacrylamide), amine terminated

average Mn 2,500 (T)

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Synonym(s):
NIPAM polymer, PNIPAM-NH2, Polyacrylamide, functionalized polyNIPAM, functionalized polyacrylamide, polyNIPAM
Linear Formula:
H(C6H11NO)nSCH2CH2NH2
UNSPSC Code:
12162002
NACRES:
NA.23

Quality Level

100

form

solid

mol wt

Mn 2000-3000 (by HCL Titration)

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Application

PNIPAM-based Smart Surfaces for Cell Sheet Tissue Engineering
Novel polymer for development of thermosensitive coated micro/nano materials including thermoresponsive polymeric drug delivery systems. The amine functional group can be used to conjugate a variety of biomolecules to the polymer chain.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Articles

Designing Temperature and pH Sensitive NIPAM Based Polymers

Poly(N-isopropylacrylamide), or PNIPAM, is a stimuli-responsive polymer that responds to changes in pH and temperature and has a LCST around 32 C.

Poly(N-isopropylacrylamide)-based Smart Surfaces for Cell Sheet Tissue Engineering

Tissue engineering has become a key therapeutic tool in the treatment of damaged or diseased organs and tissues, such as blood vessels and urinary bladders.

Stimuli-Responsive Materials as Intelligent Drug Delivery Systems

By altering the physicochemical properties, smart or intelligent drug delivery systems can be designed to deliver therapeutic molecules on-demand. Learn more about the application of stimuli-responsive materials in drug delivery.

Therapeutic Nanoparticles Harness Myeloid Cells for Brain Tumor-Targeted Delivery and Immunomodulation

Immunosuppressive tumor-associated myeloid cells (TAMC) are responsible for glioblastoma (GBM) resistance to immunotherapies and existing standard of care treatments. This mini-review highlights recent progress in implementing nanotechnology in advancing TAMC-targeted therapies for GBM.

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