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Safety Information

724467

Sigma-Aldrich

Poly(N-isopropylacrylamide-co-methacrylic acid)

methacrylic acid 5 mol %, average Mn 50,000

Synonym(s):

Poly(NIPAM-co-MAA), Polyacrylamide, functionalized polyNIPAM, functionalized polyacrylamide, polyNIPAM

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About This Item

Linear Formula:
(C6H11NO)m (C4H6O2)n
CAS Number:
151954-97-1
UNSPSC Code:
12162002
NACRES:
NA.23

form

powder

mol wt

average Mn 50,000

composition

methacrylic acid, 5 mol %

mp

>300 °C

InChI

1S/C6H11NO.C4H6O2/c1-4-6(8)7-5(2)3;1-3(2)4(5)6/h4-5H,1H2,2-3H3,(H,7,8);1H2,2H3,(H,5,6)

InChI key

BGJOTKHBFYMJST-UHFFFAOYSA-N

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Application

PNIPAM-based Smart Surfaces for Cell Sheet Tissue Engineering
Intelligent Swelling/Collapsing copolymer that can be used as a temperature- and pH-sensitive materials.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKBW8511V
MKBD3291

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Kai Zhang et al.
Biomacromolecules, 5(4), 1248-1255 (2004-07-13)
To elucidate the mechanism of stimuli-responsive permeability and to optimize the design, the nanostructure of polymeric composite membranes, developed in our laboratory, was characterized. The membranes were prepared to contain various amounts of stimuli-responsive nanoparticles of poly(N-isopropylacrylamide-co-methacrylic acid), with or
Kai Zhang et al.
The Journal of pharmacy and pharmacology, 56(5), 611-620 (2004-05-15)
A new glucose-responsive polymeric composite membrane that provided pulsatile insulin release was developed in our laboratory previously. To develop a clinically useful insulin delivery system, this study was designed to investigate factors influencing insulin stability during delivery by this membrane.
Yunlu Dai et al.
ACS nano, 6(4), 3327-3338 (2012-03-23)
In this study, we report a new controlled release system based on up-conversion luminescent microspheres of NaYF(4):Yb(3+)/Er(3+) coated with the smart hydrogel poly[(N-isopropylacrylamide)-co-(methacrylic acid)] (P(NIPAM-co-MAA)) (prepared using 5 mol % of MAA) shell. The hybrid microspheres show bright up-conversion fluorescence
Ricardo G Sousa et al.
Journal of controlled release : official journal of the Controlled Release Society, 102(3), 595-606 (2005-02-01)
The loading of an antihypertensive cationic drug, diltiazem hydrochloride (DIL.HCl), into poly(N-isopropylacrylamide) [P(N-iPAAm)], poly(methacrylic acid) [P(MAA)], and their poly[(N-isopropylacrylamide)-co-(methacrylic acid)] P[(N-iPAAm)-co-(MAA)] hydrogels as well as their release behaviour have been investigated. For this purpose, two series of hydrogels have been
Yashpal Sharma et al.
International journal of biological macromolecules, 51(4), 627-631 (2012-06-23)
Electrospinning is a versatile method to fabricate nanofibers of a range of polymeric and composite materials suitable as scaffolds for tissue engineering applications. In this study, we report the fabrication and characterization of polyaniline-carbon nanotube/poly(N-isopropyl acrylamide-co-methacrylic acid) (PANI-CNT/PNIPAm-co-MAA) composite nanofibers
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Designing Temperature and pH Sensitive NIPAM Based Polymers

Poly(N-isopropylacrylamide), or PNIPAM, is a stimuli-responsive polymer that responds to changes in pH and temperature and has a LCST around 32 C.

Poly(N-isopropylacrylamide)-based Smart Surfaces for Cell Sheet Tissue Engineering

Tissue engineering has become a key therapeutic tool in the treatment of damaged or diseased organs and tissues, such as blood vessels and urinary bladders.

Stimuli-Responsive Materials as Intelligent Drug Delivery Systems

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