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Merck
CN

705888

25-Hydroxyvitamin D3 (6,19,19-d3)

≥97 atom % D, ≥98% (CP)

Synonym(s):

25-Hydroxycholecalciferol (6,19,19-d3), 25-Hydroxycholecalciferol D3-D3, 25-Hydroxyergocalciferol D3-D3, Deuterated hydroxyvitamin D3

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About This Item

Empirical Formula (Hill Notation):
C27D3H41O2
CAS Number:
140710-94-7
Molecular Weight:
403.66
NACRES:
NA.24
PubChem Substance ID:
329762594
UNSPSC Code:
12352106
MDL number:
MFCD11656128

Key Documents

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Product Name

25-Hydroxyvitamin D3 (6,19,19-d3), ≥97 atom % D, ≥98% (CP)

InChI

1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1/i1D2,12D

SMILES string

[2H]/C([2H])=C1CC[C@H](O)CC\1=C([2H])\C=C2/CCC[C@]3(C)[C@H](CC[C@@H]23)[C@H](C)CCCC(C)(C)O

InChI key

JWUBBDSIWDLEOM-CMMPNOGOSA-N

isotopic purity

≥97 atom % D

assay

≥98% (CP)

form

powder

technique(s)

mass spectrometry (MS): suitable

color

white to off-white

mass shift

M+3

storage temp.

−20°C

Quality Level

200

Related Categories

Application

25-Hydroxyvitamin D3 (6,19,19-d3) can be used as an analytical standard.

General description

25-hydroxyvitamin D3 (calcifediol) is a prohormone produced via hydroxylation of vitamin D3 (cholecalciferol) in the liver. It is a precursor for the synthesis of calcitriol or 1,25-dihydroxyvitamin D3 or [1,25(OH)2D3]. It is used as a biomarker to determine the status of vitamin D in the body.
25-Hydroxyvitamin D3 (6,19,19-d3) is a deuterated vitamin D3 wherein C-6 and C-19 protons are replaced by deuterium.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

美国出口管控产品
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Certificates of Analysis (COA)

Lot/Batch Number
MBBF1785
MBBF0626
MBBD9368
MBBD8872
MBBD2156

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Jiri Adamec et al.
Journal of separation science, 34(1), 11-20 (2010-12-21)
Simultaneous and accurate measurement of vitamin D and 25-hydroxyvitamin D in biological samples is a barrier limiting our ability to define "optimal" vitamin D status. Thus, our goal was to optimize conditions and evaluate an LC-MS method for simultaneous detection
25-Hydroxyvitamin D3, the prohormone of 1, 25-dihydroxyvitamin D3, inhibits the proliferation of primary prostatic epithelial cells
Barreto, AM et al.
Cancer Epidemiology, Biomarkers & Prevention, 9(3), 265-270 (2000)
Quantification of circulating 25-hydroxyvitamin D by liquid chromatography-tandem mass spectrometry
Vogeser M
The Journal of Steroid Biochemistry and Molecular Biology, 121(3-5), 565-573 (2010)

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