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Safety Information

702501

Sigma-Aldrich

trans-4-Hydroxy-D-proline

97%

Synonym(s):

(2R,4S)-4-Hydroxypyrrolidine-2-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C5H9NO3
CAS Number:
3398-22-9
Molecular Weight:
131.13
MDL number:
MFCD00065608
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
329762380
NACRES:
NA.22

Assay

97%

form

powder

reaction suitability

reaction type: solution phase peptide synthesis

mp

261 °C (dec)

application(s)

peptide synthesis

SMILES string

O[C@@H]1CN[C@H](C1)C(O)=O

InChI

1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m0/s1

InChI key

PMMYEEVYMWASQN-IUYQGCFVSA-N

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H302,H315,H319,H334,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

Certificates of Analysis (COA)

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Ashley C Campbell et al.
Archives of biochemistry and biophysics, 698, 108727-108727 (2020-12-18)
Proline utilization A (PutA) proteins are bifunctional proline catabolic enzymes that catalyze the 4-electron oxidation of l-proline to l-glutamate using spatially-separated proline dehydrogenase and l-glutamate-γ-semialdehyde dehydrogenase (GSALDH, a.k.a. ALDH4A1) active sites. The observation that l-proline inhibits both the GSALDH activity
Takenori Satomura et al.
Applied microbiology and biotechnology, 99(10), 4265-4275 (2014-12-05)
A gene from the thermophilic Gram-negative bacterium Rhodothermus marinus JCM9785, encoding a dye-linked D-amino acid dehydrogenase homologue, was overexpressed in Escherichia coli, and its product was purified and characterized. The expressed enzyme was a highly thermostable dye-linked D-amino acid dehydrogenase
István Ilisz et al.
Journal of chromatography. A, 1363, 169-177 (2014-07-20)
Two chiral stationary phases containing a quinine- or a quinidine-based zwitterionic ion-exchanger as chiral selector were applied for the enantioseparation of 27 unusual cyclic secondary α-amino acids. The effects of the nature and concentration of the bulk solvent, the acid

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