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686298

Sigma-Aldrich

(R)-4-Chloro-α-methylbenzyl alcohol

95%

Synonym(s):

(R)-1-(4-Chlorophenyl)ethanol

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About This Item

Linear Formula:
ClC6H4CH(CH3)OH
CAS Number:
75968-40-0
Molecular Weight:
156.61
MDL number:
MFCD06797295
UNSPSC Code:
12352101
PubChem Substance ID:
329761035
NACRES:
NA.22

Assay

95%

form

liquid

optical activity

[α]20/D +49.0°, c = 1.6 in chloroform

refractive index

n20/D 1.544

density

1.158 g/mL at 25 °C

functional group

chloro
hydroxyl

SMILES string

C[C@@H](O)c1ccc(Cl)cc1

InChI

1S/C8H9ClO/c1-6(10)7-2-4-8(9)5-3-7/h2-6,10H,1H3/t6-/m1/s1

InChI key

MVOSNPUNXINWAD-ZCFIWIBFSA-N

Application

(R)-4-Chloro-α-methylbenzyl alcohol can be used:
  • As a substrate in the racemization process of secondary alcohols using ruthenium hydroxide complexes.
  • In the synthesis of 2,3,4,9-tetrahydro-1H-carbazole as potent DP1 antagonists.
  • As a substrate in the synthesis of chiral 3-aryl-3-substituted propanoic acids through Mitsunobu reaction.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H318

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

>230.0 °F

Flash Point(C)

> 110 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKBN9804V
15417JH

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Ruthenium Hydroxide Complexes in the Racemization of Secondary Alcohols
Nun P, et al.
Organometallics, 30(23), 6347-6350 (2011)
Stereoselective Carbon- Carbon Bond Formation via the Mitsunobu Displacement of Chiral Secondary Benzylic Alcohols
Hillier MC, et al.
Organic Letters, 6(4), 573-576 (2004)
Potent and highly selective DP1 antagonists with 2, 3, 4, 9-tetrahydro-1H-carbazole as pharmacophore
Li L, et al.
Bioorganic & Medicinal Chemistry Letters, 20(24), 7462-7465 (2010)
Xiao-Hong Chen et al.
BMC biotechnology, 11, 110-110 (2011-11-22)
Chiral alcohols are widely used in the synthesis of chiral pharmaceuticals, flavors and functional materials and appropriate whole-cell biocatalysts offer a highly enantioselective, minimally polluting route to these valuable compounds. The recently isolated strain Acetobacter sp. CCTCC M209061 showed exclusive
Xiao-Hong Chen et al.
Microbial cell factories, 11, 119-119 (2012-09-06)
The bacterium Acetobacter sp. CCTCC M209061 is a promising whole-cell biocatalyst with exclusive anti-Prelog stereoselectivity for the reduction of prochiral ketones that can be used to make valuable chiral alcohols such as (R)-4-(trimethylsilyl)-3-butyn-2-ol. Although it has promising catalytic properties, its
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