675903
4-(Methanesulfonyl)phenylboronic acid
≥95.0%
Synonym(s):
4-(Methanesulfonyl)benzeneboronic acid, 4-(Methylsulfonyl)phenylboronic acid, 4-Methansulfonylphenylboronic acid
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About This Item
Linear Formula:
(H3CSO2)C6H4B(OH)2
CAS Number:
Molecular Weight:
200.02
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352103
MDL number:
InChI
1S/C7H9BO4S/c1-13(11,12)7-4-2-6(3-5-7)8(9)10/h2-5,9-10H,1H3
SMILES string
CS(=O)(=O)c1ccc(cc1)B(O)O
InChI key
VDUKDQTYMWUSAC-UHFFFAOYSA-N
assay
≥95.0%
form
solid
mp
289-293 °C
functional group
sulfone
Quality Level
Related Categories
General description
Contains varying amounts of anhydride
Application
4-(Methanesulfonyl)phenylboronic acid may be used as reagent for:
Reagent used in Preparation of
- sequential Suzuki cross-coupling reactions
- Copper-catalyzed oxidative trifluoromethylthiolation of aryl boronic acids
- directed metalation and regioselective functionalization of 3-bromofuran and related heterocycles
- Barton-Zard pyrrole cyclocondensations and Baeyer-Villiger oxidations
- diplar cycloaddition and palladium-catalyzed cross-coupling processes
- continuous flow Suzuki reactions for odanacatib intermediate synthesis
Reagent used in Preparation of
- diarylaminopyridines as potential anti-malarial agents
- hydropyranopyrazine via chloropyrazinecarboxaldehyde and olefination
- biaryl sulfone derivatives as antagonists of the histamine H3 receptor
- novel kinase inhibitor scaffolds with potential antitumor effects
- Hepatitis C virus inhibition activity of N-hydroxyisoquinoline di
Highly effective boronic acid used in a rhodium-catalyzed asymmetric 1,4-addition to 4-oxobutenamides.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)
Semple, G.; et al.
Bioorganic & Medicinal Chemistry, 21, 71-75 (2012)
Yue-Lei Chen et al.
Bioorganic & medicinal chemistry, 20(1), 467-479 (2011-11-22)
C7-Substituted 2-hydroxyisoquinoline-1,3-diones inhibit the strand transfer of HIV integrase (IN) and the reverse-transcriptase-associated ribonuclease H (RNH). Hepatitis C virus (HCV) NS5B polymerase shares a similar active site fold to RNH and IN, suggesting that N-hydroxyimides could be useful inhibitor scaffolds
Directed metalation and regioselective functionalization of 3-bromofuran and related heterocycles with NaHMDS
Tetrahedron Letters, 53, 166-169 (2012)
Synthesis of 2,6-disubstituted-7,8-dihydro-6H-pyrano[2,3-b]pyrazines
Li, J-C.; et al.
Tetrahedron Letters, 53, 852-853 (2012)
Copper-catalyzed oxidative trifluoromethylthiolation of aryl boronic acids with TMSCF3 and elemental sulfur.
Chao Chen et al.
Angewandte Chemie (International ed. in English), 51(10), 2492-2495 (2012-01-31)
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