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675555

Sigma-Aldrich

1,2-Bis[(2R,5R)-2,5-(dimethylphospholano]ethane(cyclooctadiene)rhodium(I) tetrafluoroborate

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About This Item

Empirical Formula (Hill Notation):
C22H40BF4P2Rh
CAS Number:
305818-67-1
Molecular Weight:
556.21
UNSPSC Code:
12352005
PubChem Substance ID:
24885288

form

solid

SMILES string

[Rh+].F[B-](F)(F)F.C1CC=CCCC=C1.C[C@@H]2CC[C@@H](C)P2CCP3[C@H](C)CC[C@H]3C

InChI

1S/C14H28P2.C8H12.BF4.Rh/c1-11-5-6-12(2)15(11)9-10-16-13(3)7-8-14(16)4;1-2-4-6-8-7-5-3-1;2-1(3,4)5;/h11-14H,5-10H2,1-4H3;1-2,7-8H,3-6H2;;/q;;-1;+1/b;2-1-,8-7-;;/t11-,12-,13-,14-;;;/m1.../s1

InChI key

CVUPEPGZCZHSOF-ZTCBNWEGSA-N

Application

DuPhos and BPE Ligands: Highly Efficient Privileged Ligands

Catalyst for:
  • Preparation of substituted phenylalanine via asymmetric hydrogenation of N-acetyldehydroamino acid precursor
  • Enantioselective preparation of trifluoromethyl amino acids via asymmetric hydrogenation
  • Asymmetric hydrogenation of acetamidocinnamate

Legal Information

Sold in collaboration with Kanata Chemical Technologies, Inc. for research purposes only. These compounds were made and sold under license from E.I. du Pont de Nemours and Company, which license does not include the right to use the compounds in producing products for sale in the pharmaceutical field.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

Certificates of Analysis (COA)

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Articles

DuPhos and BPE Ligands

Asymmetric hydrogenation enables scalable synthesis of single-enantiomer compounds with minimal byproducts, ideal for commercial manufacturing.

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