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About This Item
Linear Formula:
CH3SO2NH2
CAS Number:
Molecular Weight:
95.12
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
221-553-6
Beilstein/REAXYS Number:
1740835
MDL number:
Assay:
≥97.0% (CHN)
Form:
solid
InChI key
HNQIVZYLYMDVSB-UHFFFAOYSA-N
InChI
1S/CH5NO2S/c1-5(2,3)4/h1H3,(H2,2,3,4)
SMILES string
CS(N)(=O)=O
assay
≥97.0% (CHN)
form
solid
mp
85-89 °C (lit.)
Quality Level
Related Categories
Application
- Methanesulfonamide is used in the synthesis of important organic reagents such as N-(2-methylthio-1-p-toluenesufonyl)methanesulfonamide and tert-butyl ((2-(trimethylsilyl)ethyl)sulfonyl)carbamate.
- It can be used as a source of nitrogen in the conversion of carboxylic acids to corresponding nitriles.
- It is widely used as a reagent in the synthesis of medicinally important compounds such as derivatives of indole-N-acetamide, methanesulfonamide pyrimidine-substituted 3,5-dihydroxy-6-heptenoates and repertaxin.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase.
Harper S, et al.
Journal of Medicinal Chemistry, 48(5), 1314-1317 (2005)
A Convenient Synthesis of Chloronitrobenzonitrile Isomers and Homologs.
Grivsky E M
Bull. Soc. Chim. Belg., 80(3?4), 245-252 (1971)
Synthesis and biological activity of methanesulfonamide pyrimidine-and N-methanesulfonyl pyrrole-substituted 3, 5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors.
Watanabe M, et al.
Bioorganic & Medicinal Chemistry, 5(2), 437-444 (1997)
2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors.
Allegretti M, et al.
Journal of Medicinal Chemistry, 48(13), 4312-4331 (2005)
Sevgi Karakuş et al.
European journal of medicinal chemistry, 44(9), 3591-3595 (2009-03-28)
Due to a continuing effort to develop new antiviral agents, a series of 1-[4-(methanesulfonamido)-3-phenoxyphenyl]-3-alkyl/aryl thioureas 3a-i have been synthesized by the reaction of alkyl/aryl isothiocyanates with 4-amino-2-phenoxymethanesulfonanilide. These derivatives were structurally characterized by the use of spectral techniques and evaluated
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