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630721

Sigma-Aldrich

6-Aminoindole

97%

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Synonym(s):
Indol-6-ylamine, NSC 82379
Empirical Formula (Hill Notation):
C8H8N2
CAS Number:
Molecular Weight:
132.16
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

97%

form

solid

mp

75-79 °C

storage temp.

−20°C

SMILES string

Nc1ccc2cc[nH]c2c1

InChI

1S/C8H8N2/c9-7-2-1-6-3-4-10-8(6)5-7/h1-5,10H,9H2

InChI key

MIMYTSWNVBMNRH-UHFFFAOYSA-N

Application

Reactant for preparation of:
  • Inhibitors of mammalian target of rapamycin (mTOR ) protein
  • Inhibitors of the AcrAB-TolC efflux pump
  • Inhibitors of Gli1-mediated transcription in the Hedgehog pathway
  • Potent DNA-topoisomerase II poisons and anti-MDR agents
  • Protein kinase C θ (PKCθ) inhibitors
  • Piperidine carboxamide as transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonists
  • Potent and selective blockers of the Nav1.8 sodium channel as potential analgesics for the treatment of neuropathic and inflammatory pain
  • 5,6-fused heteroaromatic ureas as TRPV1 antagonists
  • Allosteric enhancers of the A3 adenosine receptor
  • Human liver glycogen phosphorylase (HLGP) inhibitors for the treatment of type 2 diabetes

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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