Skip to Content
Merck
CN
All Photos(4)

Documents

608033

Sigma-Aldrich

L-Arginine-13C6,15N4 hydrochloride

99 atom % 13C, 99 atom % 15N, 95% (CP)

Sign Into View Organizational & Contract Pricing
All Photos(4)
Synonym(s):
SILAC Amino Acid, (S)-(+)-2-Amino-5-[(aminomethyl)amino]pentanoic acid-13C6,15N4 hydrochlordie, 13C and 15N Labeled ARG, 13C and 15N Labeled arginine hydrochloride
Linear Formula:
H215N13C(15NH)15NH(13CH2)313CH(15NH2)13CO2H · HCl
CAS Number:
202468-25-5
Molecular Weight:
220.59
MDL number:
MFCD04118221
UNSPSC Code:
12352209
PubChem Substance ID:
329759227
NACRES:
NA.12

isotopic purity

99 atom % 13C
99 atom % 15N

Quality Level

200

Assay

95% (CP)

form

solid

optical activity

[α]20/D +22°, c = 12 in 10% HCl

composition

L-isomer, 97%

technique(s)

bio NMR: suitable
protein expression: suitable

mp

226-230 °C (dec.) (lit.)

mass shift

M+10

SMILES string

Cl.[15NH2][13C@@H]([13CH2][13CH2][13CH2][15NH][13C]([15NH2])=[15NH])[13C](O)=O

InChI

1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1/i1+1,2+1,3+1,4+1,5+1,6+1,7+1,8+1,9+1,10+1;

InChI key

KWTQSFXGGICVPE-YAUSPDTOSA-N

Related Categories

Application

Pulsed Stable Isotope labeling of amino acid has been used to study host-cell function, survival, the precise intracellular pathways in protein synthesis of HIV-1 infected human monocytederived macrophages.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Stephanie D Kraft-Terry et al.
Journal of proteome research, 10(6), 2852-2862 (2011-04-20)
Dynamic interactions between human immunodeficiency virus-1 (HIV-1) and the macrophage govern the tempo of viral dissemination and replication in its human host. HIV-1 affects macrophage phenotype, and the macrophage, in turn, can modulate the viral life cycle. While these processes
Vittoria Matafora et al.
STAR protocols, 1(3), 100162-100162 (2020-12-31)
Secretome analysis is crucial to unravel extracellular processes. However, secreted proteins are difficult to detect in mass-spectrometry-based analysis due to contamination of serum proteins deriving from cell culture media and to high glycosylation, which hampers tryptic digestion. Secret3D workflow is
Alex A Makarov et al.
Nature communications, 10(1), 3056-3056 (2019-07-13)
Lamin A is a nuclear intermediate filament protein critical for nuclear architecture and mechanics and mutated in a wide range of human diseases. Yet little is known about the molecular architecture of lamins and mechanisms of their assembly. Here we
Zehan Hu et al.
Cell reports, 28(13), 3486-3496 (2019-09-26)
The target of rapamycin complex 1 (TORC1) is a master regulator of cell homeostasis, which promotes anabolic reactions and synchronously inhibits catabolic processes such as autophagy-mediated protein degradation. Its prime autophagy target is Atg13, a subunit of the Atg1 kinase
Roberto Ravasio et al.
Science advances, 6(15), eaax2746-eaax2746 (2020-04-15)
The histone demethylase LSD1 is deregulated in several tumors, including leukemias, providing the rationale for the clinical use of LSD1 inhibitors. In acute promyelocytic leukemia (APL), pharmacological doses of retinoic acid (RA) induce differentiation of APL cells, triggering degradation of
View All Related Papers

Related Content

Protein Structural Analysis

Protein structure analysis aids in identifying disease biomarkers and drug targets crucial for therapeutic treatments.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service