579602
(R)-(+)-1,2-Dithiolane-3-pentanoic acid
97%
Synonym(s):
(R)-6,8-Dithiooctanoic acid, (R)-6,8-Thioctic acid
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About This Item
Empirical Formula (Hill Notation):
C8H14O2S2
CAS Number:
Molecular Weight:
206.33
UNSPSC Code:
12352005
PubChem Substance ID:
MDL number:
Assay:
97%
Form:
solid
form
solid
InChI
1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1
InChI key
AGBQKNBQESQNJD-SSDOTTSWSA-N
assay
97%
optical activity
[α]20/D +104°, c = 1 in chloroform
mp
48-52 °C (lit.)
Storage Class
11 - Combustible Solids
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Michela Rosini et al.
Journal of medicinal chemistry, 48(2), 360-363 (2005-01-22)
The coupling of two different pharmacophores, each endowed with different biological properties, afforded the hybrid compound lipocrine (7), whose biological profile was markedly improved relative to those of prototypes tacrine and lipoic acid. Lipocrine is the first compound that inhibits
Alessandra Antonello et al.
Journal of medicinal chemistry, 48(1), 28-31 (2005-01-07)
To combine in the same molecule alpha(1)-adrenoreceptor blocking and antioxidant properties, compounds 2-5 were designed and synthesized. All compounds were effective alpha(1)-adrenoreceptor antagonists and were tested in both functional and binding assays. In addition, compounds 2 and 5 also displayed
Sylvaine F A Bruggraber et al.
Gastroenterology, 125(6), 1705-1713 (2004-01-16)
Although considerable effort has been directed toward the mapping of peptide epitopes by autoantibodies, the role of nonprotein molecules has been less well studied. The immunodominant autoantigen in primary biliary cirrhosis (PBC), E2 components of pyruvate dehydrogenase complexes (PDC-E2), has
P R Redden et al.
International journal of pharmaceutics, 180(2), 151-160 (1999-06-17)
A series of acyloxymethyl drug derivatives of the NH-acidic drugs, phenytoin and theophylline and of the carboxylic acid drugs, thioctic acid and indomethacin, were prepared in order to determine the effect of varying the nature of the drug on the
T V Semenova et al.
Ukrainskii biokhimicheskii zhurnal (1978), 65(5), 26-30 (1993-09-01)
Effect of lipoic acid, 5,5-dithiobis-2-nitrobenzoic acid, monoiodoacetic acid and cystine on thermal stability of human serum albumin was studied by differential scanning calorimetry and electrophoretic methods. Quantitative estimation of the protective effect of these reagents on resistance of 5% solutions
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