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Merck
CN

568562

Poly(L-lactide-co-caprolactone-co-glycolide)

L-lactide 70 %, average Mn ~50,000 by GPC

Synonym(s):

ε-Caprolactone-glycolide-L -lactide copolymer, Poly-L -lactide-co-glycolide-co-ε-caprolactone

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About This Item

CAS Number:
UNSPSC Code:
12162002
NACRES:
NA.23
MDL number:
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Product Name

Poly(L-lactide-co-caprolactone-co-glycolide), L-lactide 70 %, average Mn ~50,000 by GPC

form

solid

feed ratio

lactide:caprolactone:glycolide 70:20:10

mol wt

average Mn ~50,000 by GPC

composition

L-lactide, 70%

transition temp

Tg ~28 °C

storage temp.

2-8°C

Quality Level

Application

Poly(L-lactide-co-caprolactone-co-glycolide) (PLGA-PCL) is a biodegradable block copolymer that may be used as nanoparticle-based drug delivery systems. Electrospun nanofiber blend of PLGA-PCL, phosphorylcholine groups and an antiproliferative (rapamycin)may be used as vascular grafts and prostheses.

Features and Benefits

Biocompatible, biodegradable polymer.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Preparation of electrospun poly (L-lactide-co-caprolactone-co-glycolide)/phospholipid polymer/rapamycin blended fibers for vascular application.
Kim H I, et al.
Current Applied Physics, 9(4), e249-e251 (2009)
Novel docetaxel-loaded nanoparticles based on poly (lactide-co-caprolactone) and poly (lactide-co-glycolide-co-caprolactone) for prostate cancer treatment: formulation, characterization, and cytotoxicity studies.
Sanna V, et al.
Nanoscale Research Letters, 6(1), 260-260 (2011)

Articles

In the past two decades, tissue engineering and regenerative medicine have become important interdisciplinary fields that span biology, chemistry, engineering, and medicine.

Innovations in polymer technology have had a significant impact on the advancement of novel drug delivery systems.

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