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Poly(L-lactide-co-caprolactone-co-glycolide)

L-lactide 70 %, average Mn ~50,000 by GPC

Synonym(s):

ε-Caprolactone-glycolide-L -lactide copolymer, Poly-L -lactide-co-glycolide-co-ε-caprolactone

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About This Item

CAS Number:
134490-19-0
MDL number:
MFCD04041034
UNSPSC Code:
12162002
NACRES:
NA.23

form

solid

Quality Level

100

feed ratio

lactide:caprolactone:glycolide 70:20:10

mol wt

average Mn ~50,000 by GPC

composition

L-lactide, 70%

transition temp

Tg ~28 °C

storage temp.

2-8°C

Related Categories

Application

Poly(L-lactide-co-caprolactone-co-glycolide) (PLGA-PCL) is a biodegradable block copolymer that may be used as nanoparticle-based drug delivery systems. Electrospun nanofiber blend of PLGA-PCL, phosphorylcholine groups and an antiproliferative (rapamycin)may be used as vascular grafts and prostheses.

Features and Benefits

Biocompatible, biodegradable polymer.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Preparation of electrospun poly (L-lactide-co-caprolactone-co-glycolide)/phospholipid polymer/rapamycin blended fibers for vascular application.
Kim H I, et al.
Current Applied Physics, 9(4), e249-e251 (2009)
Novel docetaxel-loaded nanoparticles based on poly (lactide-co-caprolactone) and poly (lactide-co-glycolide-co-caprolactone) for prostate cancer treatment: formulation, characterization, and cytotoxicity studies.
Sanna V, et al.
Nanoscale Research Letters, 6(1), 260-260 (2011)

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