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559210

Sigma-Aldrich

Ethyl (4-chlorobenzoyl)acetate

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Synonym(s):
3-(4-Chlorophenyl)-3-oxopropanoic acid ethyl ester, Ethyl 3-(4-chlorophenyl)-3-oxopropanoate, NSC 406743
Linear Formula:
ClC6H4COCH2CO2C2H5
CAS Number:
2881-63-2
Molecular Weight:
226.66
MDL number:
MFCD00018713
UNSPSC Code:
12352100
PubChem Substance ID:
24879805
NACRES:
NA.22

form

solid

Quality Level

100

refractive index

n20/D 1.5500 (lit.)

bp

268-269 °C (lit.)

density

1.218 g/mL at 25 °C (lit.)

SMILES string

CCOC(=O)CC(=O)c1ccc(Cl)cc1

InChI

1S/C11H11ClO3/c1-2-15-11(14)7-10(13)8-3-5-9(12)6-4-8/h3-6H,2,7H2,1H3

InChI key

DGCZHKABHPDNCC-UHFFFAOYSA-N

Related Categories

Application

Ethyl (4-chlorobenzoyl)acetate may be used to synthesize 2-(carboethoxy)-3-(4′-chloro)phenylquinoxaline 1,4-dioxide.
Reactant involved in:
  • Tandem condensation-cyclization reactions
  • Stereoselective ketonization-olefination of indoles
  • Synthesis of antiplasmodial agents
  • SIRT 1/2 inhibitor preparation for use as antitumor agents
  • Synthesis of mineralocorticoid receptor antagonists
  • Intramolecular Michael addition reactions

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Comparative Use of Solvent-free KF-Al2O3 and K2CO3 in Acetone in the Synthesis of Quinoxaline 1, 4-Dioxide Derivatives Designed as Antimalarial Drug Candidates.
Lima LM, et al.
Journal of Heterocyclic Chemistry, 42(7), 1381-1385 (2005)

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