55088
8-Hydroxy-2-quinolinecarboxylic acid
≥98.0% (HPLC)
Synonym(s):
8-Hydroxyquinaldic acid
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About This Item
Empirical Formula (Hill Notation):
C10H7NO3
CAS Number:
Molecular Weight:
189.17
Beilstein:
146082
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Quality Level
Assay
≥98.0% (HPLC)
form
solid
SMILES string
OC(=O)c1ccc2cccc(O)c2n1
InChI
1S/C10H7NO3/c12-8-3-1-2-6-4-5-7(10(13)14)11-9(6)8/h1-5,12H,(H,13,14)
InChI key
UHBIKXOBLZWFKM-UHFFFAOYSA-N
Related Categories
General description
8-Hydroxy-2-quinolinecarboxylic acid (8HQC) is a tridentate chelating agent. It reacts with 2-aminophenol to form a benzoxazole derivative, which can undergo fluorescence quenching in water, making it a viable candidate for developing a probe for detecting water in aprotic organic solvents. The analysis of mid-IR and Raman spectra of 8HQC shows the presence of seven tautomers.
Application
8-Hydroxy-2-quinolinecarboxylic acid may be used in the preparation of bis (8-hydroxyquinoline-2-carboxylato-Κ3N,O,O′) cobalt (II) trihydrate.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Determination of water content in aprotic organic solvents using 8-hydroxyquinoline based fluorescent probe.
Kim JS, et al.
Bull. Korean Chem. Soc., 27(12), 2058-2058 (2006)
Bis (8-hydroxyquinoline-2-carboxylato-?3N,O,O') cobalt (II) trihydrate.
Okabe N and Muranishi Y.
Acta Crystallographica Section E, Structure Reports Online, 58(7), m352-m353 (2002)
Katarzyna Walczak et al.
Molecules (Basel, Switzerland), 25(7) (2020-04-09)
8-Hydroxyquinaldic acid, the end-metabolite of tryptophan, is well-known metal chelator; however, its role in humans, especially in cancer promotion and progression, has not been fully revealed. Importantly, 8-hydroxyquinaldic acid is the analog of kynurenic acid with evidenced antiproliferative activity towards
A combined experimental and theoretical study on 8-hydroxy-2-quinolinecarboxylic acid.
Badoglu S and Yurdakul S.
Optics and Spectroscopy, 116(2), 196-206 (2014)
Francesco Bellia et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 26(70), 16690-16705 (2020-07-07)
Metal dysregulation, oxidative stress, protein modification, and aggregation are factors strictly interrelated and associated with neurodegenerative pathologies. As such, all of these aspects represent valid targets to counteract neurodegeneration and, therefore, the development of metal-binding compounds with other properties to
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