All Photos(1)
Linear Formula:
CF3C(CH3)2OH
CAS Number:
Molecular Weight:
128.09
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Quality Level
Assay
96%
refractive index
n20/D 1.3335 (lit.)
bp
83 °C (lit.)
density
1.17 g/mL at 25 °C (lit.)
SMILES string
CC(C)(O)C(F)(F)F
InChI
1S/C4H7F3O/c1-3(2,8)4(5,6)7/h8H,1-2H3
InChI key
OCGWWLDZAFOHGD-UHFFFAOYSA-N
Related Categories
General description
2-Trifluoromethyl-2-propanol is a fluorinated aliphatic alcohol. It can be prepared by reacting methyllithium, trifluoroacetone and trifluorovinyl bromide in ether. This can also be synthesized from the reaction between methylmagnesium bromide and 1,1,1-trifluoroacetone in ether.
Application
2-Trifluoromethyl-2-propanol may be employed as a solvent for the preparation of [18F]fluorothymidine. It may also be used in the synthesis of [2-(trifluoromethyl)-2-propyl nitrate] through nitration in nitric acid/trifluoroacetic anhydride.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Flam. Liq. 2
WGK
WGK 3
Flash Point(F)
59.0 °F
Flash Point(C)
15 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
危险化学品
Certificates of Analysis (COA)
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The Preparation and Some Reactions of Trifluorovinyllithium1
Tarrant P, et al.
The Journal of Organic Chemistry, 28.3, 839-843 (1963)
Mechanistic studies on gas-phase negative ion unimolecular decompositions. Alkoxide anions
Tumas W, et al.
Journal of the American Chemical Society, 110.9 , 2714-2722 (1988)
Nonacidic nitration of secondary amines
Bottaro JC, et al.
The Journal of Organic Chemistry, 52.11 , 2292-2294 (1987)
Comparison of synthesis yields of 3'-deoxy-3'-[18F] fluorothymidine by nucleophilic fluorination in various alcohol solvents
Lee SJ, et al.
Journal of Labelled Compounds & Radiopharmaceuticals, 51.1, 80-82 (2008)
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