536822
PAMAM-OH dendrimer, generation 6 solution
5 wt. % in methanol
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Linear Formula:
[NH2(CH2)2NH2]:(G=6);dendri PAMAM(NHCH2CH2OH)256
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description
amidoethanol surface groups
Quality Level
form
liquid
mol wt
generation 6
feature
core type ethylenediamine core (2-carbon core)
concentration
5 wt. % in methanol
no. Surface Groups
256
refractive index
n20/D 1.336
density
0.807 g/mL at 25 °C
storage temp.
2-8°C
Related Categories
General description
PAMAM-OH (poly(amidoamine) dendrimers are highly branched core-shell nanostructures with surface hydroxyl groups. The presence of hydroxyl groups on the surface of the PAMAM-OH dendrimer molecule leads to stronger interaction with the components of the cell membrane via the formation of hydrogen bonds. This type of interaction can modify the properties and function of cell membranes. PAMAM-OH dendrimers also have an advantage over PAMAM dendrimers in terms of cytotoxicity and aggregation problems because of the absence of amine functionality.
Application
PAMAM-OH dendrimer can be used to formulate poorly water-soluble drugs to increase water solubility, and therefore enhance the bioavailability of these drugs. It can also be applied to catalysts and organic molecules, where dendrimers function as solubility enhancers and modifiers.
Physical form
Contains 256 surface hydroxyl groups.
Legal Information
Manufactured by Dendritech®, Inc.
Dendritech is a registered trademark of Dendritech, Inc.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Target Organs
Eyes
WGK
WGK 3
Flash Point(F)
51.8 °F
Flash Point(C)
11 °C
Regulatory Information
危险化学品
Certificates of Analysis (COA)
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Comparative pharmacokinetics of PAMAM-OH dendrimers and HPMA copolymers in ovarian tumor-bearing mice
Sadekar S, et al.
Drug delivery and translational research, 3(3), 260-271 (2013)
Polyplexes assembled with internally quaternized PAMAM-OH dendrimer and plasmid DNA have a neutral surface and gene delivery potency
Lee Jung Hoon, et al.
Bioconjugate Chemistry, 14(6), 1214-1221 (2003)
The influence of PAMAM-OH dendrimers on the activity of human erythrocytes ATPases
Ciolkowski M, et al.
Biochimica et Biophysica Acta - Biomembranes, 1808(11), 2714-2723 (2011)
Polyamidoamine dendrimers for enhanced solubility of small molecules and other desirable properties for site-specific delivery: Insights from experimental and computational studies
Shadrack DM, et al.
Molecules (Basel), 23(6), 1419-1419 (2018)
Synthesis and characterization of Cu, Ag and Au dendrimer-encapsulated nanoparticles and their application in the reduction of 4-nitrophenol to 4-aminophenol
Nemanashi M and Meijboom R
Journal of Colloid and Interface Science, 389(1), 260-267 (2013)
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