53530
DL-Homocysteine thiolactone hydrochloride
≥99.0% (AT)
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Synonym(s):
DL-2-Amino-4-mercaptobutyric acid 1,4-thiolactone hydrochloride
Empirical Formula (Hill Notation):
C4H7NOS · HCl
CAS Number:
Molecular Weight:
153.63
Beilstein:
3689338
EC Number:
MDL number:
UNSPSC Code:
12352100
eCl@ss:
42021308
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Quality Level
Assay
≥99.0% (AT)
form
solid
loss
≤0.5% loss on drying
mp
202 °C (dec.) (lit.)
~203 °C (dec.)
SMILES string
Cl[H].NC1CCSC1=O
InChI
1S/C4H7NOS.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H
InChI key
ZSEGSUBKDDEALH-UHFFFAOYSA-N
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General description
DL-Homocysteine thiolactone hydrochloride (HTL-HCl) is a cyclic amino acid derivative that exhibits root-growth inhibitory activity.
Application
DL-Homocysteine thiolactone hydrochloride may be used in the preparation of:
- DL-buthionine
- DL-homocysteine
- poly[α,β-(N-2-aminoethyl-dl-aspartamide)]-poly[α,β-(N-2-hydroxyethyl-dl-aspartamide)]-poly[α,β-(N-3-mercapto-1-methoxycarbonyl-propyl-dl-aspartamide)] copolymer diclofenac conjugate (PAHMA-Dic)
- bis[ S-(dimethylarsino)homocysteine]
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Reza Yousefi et al.
International journal of biological macromolecules, 51(3), 291-298 (2012-05-29)
In the current study both structural alteration and fibrillation of insulin were studied in the presence of homocysteine thiolactone (HCTL). The spectroscopic studies revealed that HCTL increases rate of insulin unfolding, giving rise to the appearance of solvent-exposed hydrophobic regions
Jerott R Moore et al.
Journal of neuroimmunology, 324, 100-114 (2018-09-30)
We investigated how one calcitriol dose plus vitamin D3 reverses experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis model. This protocol rapidly increased CD4+ T cell Ikzf2 transcripts, Helios protein, and CD4+Helios+FoxP3+ T regulatory cells. It also rapidly increased CD4+ T
Joanna Malinowska et al.
Platelets, 22(4), 277-283 (2011-05-12)
Resveratrol (3,4',5-trihydroxystilben), a phenolic antioxidant synthesized in grapes and other plants, and also present in wine, has been suggested to help prevent cardiovascular events. In this study the influence of resveratrol on platelet aggregation during a model of hyperhomocysteinemia was
O W Griffith et al.
The Journal of biological chemistry, 254(16), 7558-7560 (1979-08-25)
Buthionine sulfoximine (S-n-butyl homocysteine sulfoximine), the most potent of a series of analogs of methionine sulfoximine thus far studied (Griffith, O.W., Anderson, M.E., and Meister, A. (1979) J. Biol. Chem. 254, 1205-1210), inhibited gamma-glutamylcysteine synthetase about 20 times more effectively
Root-growth inhibition by DL-homocysteine thiolactone and its related compounds.
Inamori Y, et al.
Bioscience, Biotechnology, and Biochemistry, 59(3), 523-525 (1995)
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