527793
2,3-Dichlorobenzonitrile
Synonym(s):
2,3-Dichlorophenyl cyanide
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About This Item
Linear Formula:
Cl2C6H3CN
CAS Number:
Molecular Weight:
172.01
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
form
solid
mp
60-64 °C (lit.)
SMILES string
Clc1cccc(C#N)c1Cl
InChI
1S/C7H3Cl2N/c8-6-3-1-2-5(4-10)7(6)9/h1-3H
InChI key
OHDYZVVLNPXKDX-UHFFFAOYSA-N
General description
2,3-Dichlorobenzonitrile is formed as an intermediate during the synthesis of 2,3-dichlorobenzoic acid.
Application
2,3-Dichlorobenzonitrile may be used to synthesize 2-fluoro-3-chlorobenzonitrile and 6-amino-10-chlorobenzo[c]quinolizinium chloride.
Reactant involved in:
- Nucleophilic aromatic fluorination
- Reactions with magnesium amides for synthesis of carboxamides
- Suzuki-Miyaura coupling reactions
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Preparation of 2, 3-Dichlorobenzoic acid.
Deng H, et al.
Chinese Journal of Pharmaceuticals / Chung-kuo i yao kung yeh tsa chih, 3, 006-006 (2005)
F Becq et al.
The Journal of biological chemistry, 274(39), 27415-27425 (1999-09-17)
Chloride channels play an important role in the physiology and pathophysiology of epithelia, but their pharmacology is still poorly developed. We have chemically synthesized a series of substituted benzo[c]quinolizinium (MPB) compounds. Among them, 6-hydroxy-7-chlorobenzo[c]quinolizinium (MPB-27) and 6-hydroxy-10-chlorobenzo[c]quinolizinium (MPB-07), which we
Room-temperature nucleophilic aromatic fluorination: experimental and theoretical studies.
Haoran Sun et al.
Angewandte Chemie (International ed. in English), 45(17), 2720-2725 (2006-03-21)
Jishi Wang et al.
Journal of chromatography. A, 1521, 10-18 (2017-09-25)
In this research, the manual two-step QuEChERS approach has been streamlined and automated into a one-step method using a cleanup tube fitted within an extraction tube. A novel automatic QuEChERS combination have been developed to simplify the QuEChERS procedures and
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