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Merck
CN

52730

Hexamethylphosphoramide

purum, ≥98.0% (GC)

Synonym(s):

HMPA, Hexamethylphosphoric acid triamide, Tris(dimethylamino)phosphine oxide

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About This Item

Linear Formula:
[(CH3)2N]3PO
CAS Number:
680-31-9
Molecular Weight:
179.20
UNSPSC Code:
12352111
NACRES:
NA.22
PubChem Substance ID:
57651380
EC Number:
211-653-8
Beilstein/REAXYS Number:
1099903
MDL number:
MFCD00008303

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Product Name

Hexamethylphosphoramide, purum, ≥98.0% (GC)

InChI key

GNOIPBMMFNIUFM-UHFFFAOYSA-N

InChI

1S/C6H18N3OP/c1-7(2)11(10,8(3)4)9(5)6/h1-6H3

SMILES string

CN(C)P(=O)(N(C)C)N(C)C

vapor density

6.18 (vs air)

vapor pressure

0.07 mmHg ( 25 °C)

grade

purum

assay

≥98.0% (GC)

impurities

≤2.0% water (Karl Fischer)

refractive index

n20/D 1.459 (lit.)
n20/D 1.459

bp

230-232 °C/740 mmHg (lit.)

mp

7 °C (lit.)

density

1.03 g/mL at 25 °C (lit.)

functional group

phosphoramide

Quality Level

100

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pictograms

Health hazardCorrosion
GHS08,GHS05

signalword

Danger

Hazard Classifications

Carc. 1B - Eye Dam. 1 - Muta. 1B - Skin Corr. 1C

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

291.2 °F - closed cup

flash_point_c

144 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN6402
BCCK7486
BCCH3647
BCCD4456
BCCB5292

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Bahar Zarabi et al.
Pharmaceutical research, 26(5), 1121-1129 (2009-01-23)
To evaluate the tumor targeting potential of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-gadolinium(Gd)-RGDfK conjugates by magnetic resonance (MR) T1-mapping. HPMA copolymers with and without RGDfK were synthesized to incorporate side chains for Gd chelation. The conjugates were characterized by their side-chain contents and
Jens Blotevogel et al.
Environmental science & technology, 45(6), 2236-2242 (2011-02-22)
At contaminated field sites where active remediation measures are not feasible, monitored natural attenuation is sometimes the only alternative for surface water or groundwater decontamination. However, due to slow degradation rates of some contaminants under natural conditions, attenuation processes and
Amanda C Jones et al.
Journal of the American Chemical Society, 130(19), 6060-6061 (2008-04-19)
Low-temperature rapid-injection NMR (RINMR) experiments were performed on tris(trimethylsilyl)methyllithium. In THF/Me2O solutions, the separated ion (1S) reacted faster than can be measured at -130 degrees C with MeI and substituted benzaldehydes (k >/= 2 s -1), whereas the contact ion
Jens Blotevogel et al.
Environmental science & technology, 44(15), 5868-5874 (2010-07-09)
Models used to predict the fate of aqueous phase contaminants are often limited by their inability to address the widely varying redox conditions in natural and engineered systems. Here, we present a novel approach based on quantum chemical calculations that
Anthony J Pearson et al.
Organic letters, 6(13), 2121-2124 (2004-06-18)
[reaction: see text] Vicinal stereocontrol during nucleophilic addition of tert-butyl lithiopropionate to eta(6)-anisole chromium tricarbonyl complexes with differing para substituents has been studied. Excellent vicinal double stereoinduction (>99:1) was observed when the para substituent was Si(CH(3))(3), and this has been
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