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4-Methyl-1-naphthoic acid

Name: 4-Methyl-1-naphthoic acid
Brand: ALDRICH

97%

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About This Item

Linear Formula:

CH₃C₁₀H₆CO₂H

CAS Number:

4488-40-8

Molecular Weight:

186.21

MDL number:

MFCD00671557

UNSPSC Code:

12352100

PubChem Substance ID:

24874559

NACRES:

NA.22

Assay

97%

mp

179-181 °C (lit.)

SMILES string

Cc1ccc(C(O)=O)c2ccccc12

InChI

1S/C12H10O2/c1-8-6-7-11(12(13)14)10-5-3-2-4-9(8)10/h2-7H,1H3,(H,13,14)

InChI key

SIVYRLBDAPKADZ-UHFFFAOYSA-N

Related Categories

Organic Building Blocks

General description

4-Methyl-1-naphthoic acid is a naphthoic acid derivative

Application

4-Methyl-1-naphthoic acid may be used to synthesize:

2-methyl-1-propyl-3-(4-methyl-1-naphthoyl)indole, JWH-148
4-methyl-1-naphthylcarbinol
1,4-dioxan-2-yl 4-methyl-1-naphthoate

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Preparation of a series of substituted fluoromethylnaphthalenes.

Dixon EA, et al.

Canadian Journal of Chemistry, 59(17), 2629-2641 (1981)

Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.

John W Huffman et al.

Bioorganic & medicinal chemistry, 13(1), 89-112 (2004-12-08)

In an effort to improve indole-based CB(2) cannabinoid receptor ligands and also to develop SAR for both the CB(1) and CB(2) receptors, 47 indole derivatives were prepared and their CB(1) and CB(2) receptor affinities were determined. The indole derivatives include

Iron-catalyzed cross-dehydrogenative coupling esterification of unactive C(sp3)-H bonds with carboxylic acids for the synthesis of α-acyloxy ethers.

Jincan Zhao et al.

The Journal of organic chemistry, 79(9), 3847-3855 (2014-04-15)

An iron-catalyzed oxidative esterification reaction between unactivated C(sp(3))-H bonds from symmetric and asymmetric ethers and carboxylic acids using di-tert-butyl peroxide (DTBP) as the oxidant via a cross dehydrogenative coupling (CDC) reaction was established, which tolerates a wide range of cyclic

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