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524972

Sigma-Aldrich

Diethyl phthalate

99.5%

Synonym(s):

1,2-Benzodioic acid diethyl ester, 1,2-Diethyl benzene-1,2-dicarboxylate, Diethyl 1,2-benzenedicarboxylate, Ethyl phthalate, Neantine, o-Benzenedicarboxylic acid diethyl ester

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About This Item

Linear Formula:
C6H4-1,2-(CO2C2H5)2
CAS Number:
Molecular Weight:
222.24
Beilstein:
1912500
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Assay:
99.5%
bp:
298-299 °C (lit.)
vapor pressure:
1 mmHg ( 100 °C)

vapor density

7.66 (vs air)

Quality Level

vapor pressure

1 mmHg ( 100 °C)

Assay

99.5%

form

liquid

autoignition temp.

854 °F

expl. lim.

0.75 %, 187 °F

impurities

≤0.18% water

color

APHA: ≤15

refractive index

n20/D 1.502 (lit.)

bp

298-299 °C (lit.)

mp

−3 °C (lit.)

density

1.12 g/mL at 25 °C (lit.)

functional group

ester

SMILES string

CCOC(=O)c1ccccc1C(=O)OCC

InChI

1S/C12H14O4/c1-3-15-11(13)9-7-5-6-8-10(9)12(14)16-4-2/h5-8H,3-4H2,1-2H3

InChI key

FLKPEMZONWLCSK-UHFFFAOYSA-N

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General description

Diethyl phthalate (DEP) is a phthalic anhydride ester (PAE) that is commonly used as a solvent in cosmetics and also as a plasticizer.

Application

Diethyl phthalate can be used as a solvent for the antimony reduction of aluminum chloride-phosphorus trichloride-alkyl chloride complexes to form the corresponding alkylphosphonous dichlorides. It can undergo condensation with o-phenylenediamine in the presence of sodium hydride to form dibenzo (b,f)(1,4)diazocine-6,11(5H, 12H)-dione.

Other Notes

Plasticizer.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

338.0 °F - closed cup

Flash Point(C)

170 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

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  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. I want to use Product 524972, Diethyl phthalate in cell culture or tissue culture.  In what solvent can I dilute diethyl phthlate?

    Product 524972, Diethyl phthalate, is soluble in ethanol to 0.1 M.  Lee, S.-M., et al., Dibutyl Phthalate Biodegradation by the White Rot Fungus, Polyporus brumalis.  Biotechnology and Bioengineering, 97(6), 1516-1522 (2007).

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The synthesis of alkylphosphonous dichlorides from aluminum chloride?phosphorus trichloride?alkyl chloride complexes.
Perry B J, et al.
Canadian Journal of Chemistry, 41(9), 2299-2302 (1963)
Diazocine chemistry. V. Synthesis and rearrangement of dibenzo [b, f][1, 4] diazocine-6, 11 (5H, 12H)-dione.
Paudler W W and Zeiler A G
The Journal of Organic Chemistry, 34(7), 2138-2140 (1969)
Raphael J Witorsch et al.
Critical reviews in toxicology, 40 Suppl 3, 1-30 (2010-10-12)
This article reviews laboratory and epidemiological research into the endocrine disruptive effects of components of personal care products, namely, phthalate esters, parabens, ultraviolet (UV) filters, polycyclic musks, and antimicrobials. High doses of phthalates in utero can produce “phthalate syndrome,” demasculinizing
Kashappa-Goud H Desai et al.
Journal of controlled release : official journal of the Controlled Release Society, 165(1), 62-74 (2012-10-30)
Herein, we describe the detailed development of a simple and effective method to microencapsulate vaccine antigens in poly(lactic-co-glycolic acid) (PLGA) by simple mixing of preformed active self-microencapsulating (SM) PLGA microspheres in a low concentration aqueous antigen solution at modest temperature
Ying Guo et al.
Environmental science & technology, 45(8), 3788-3794 (2011-03-26)
Because of volatilization and leaching from their application in consumer and personal care products, phthalate esters are ubiquitous contaminants in the indoor environment. In this study, we measured concentrations and profiles of 9 phthalate esters in indoor dust samples collected

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