49560
L-Glutamic acid dimethyl ester hydrochloride
≥99.0% (anhydrous basis material, AT)
Synonym(s):
L-Glu(OMe)OMe·HCl
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About This Item
Linear Formula:
CH3COOCH2CH2CH(NH2)COOCH3 · HCl
CAS Number:
Molecular Weight:
211.64
UNSPSC Code:
12352209
NACRES:
NA.22
PubChem Substance ID:
EC Number:
245-461-0
Beilstein/REAXYS Number:
4238829
MDL number:
InChI key
MFUPLHQOVIUESQ-JEDNCBNOSA-N
InChI
1S/C7H13NO4.ClH/c1-11-6(9)4-3-5(8)7(10)12-2;/h5H,3-4,8H2,1-2H3;1H/t5-;/m0./s1
SMILES string
Cl.COC(=O)CC[C@H](N)C(=O)OC
assay
≥99.0% (anhydrous basis material, AT)
optical activity
[α]20/D +26.0±1°, c = 5% in H2O
reaction suitability
reaction type: solution phase peptide synthesis
impurities
~2% water
application(s)
peptide synthesis
storage temp.
2-8°C
Quality Level
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Kazuhiro Eto et al.
American journal of physiology. Endocrinology and metabolism, 285(2), E262-E271 (2003-03-20)
We studied acute changes of secretory vesicle pH in pancreatic beta-cells with a fluorescent pH indicator, lysosensor green DND-189. Fluorescence was decreased by 0.66 +/- 0.10% at 149 +/- 16 s with 22.2 mM glucose stimulation, indicating that vesicular pH
D Bosco et al.
The American journal of physiology, 268(3 Pt 1), C611-C618 (1995-03-01)
We used a hemolytic plaque assay for insulin to determine whether the same pancreatic B cells respond to D-glucose, 2-amino-bicyclo[2,2,1]heptane-2-carboxylic acid (BCH) and the association of this nonmetabolized analogue of L-leucine with either the monomethyl ester of succinic acid (SME)
D Vicent et al.
Diabetes research and clinical practice, 27(1), 27-30 (1995-01-01)
The dimethyl ester of L-glutamic acid (GME) stimulates insulin release in isolated pancreatic islets and may represent a novel experimental tool in the study of non-insulin-dependent diabetes. In the present study, GME was found both to stimulate insulin secretion and
Chi-Li Gong et al.
Autonomic neuroscience : basic & clinical, 101(1-2), 85-90 (2002-12-05)
This study explored which subtyes of glutamate receptors in the dorsal facial area are involved in the interaction between glutamatergic and serotonergic actions in controlling common carotid arterial blood flow. Microinjection of glutamate (25-100 nmol), N-methyl-D-aspartate (NMDA; 1-4 nmol), or
G N Akoev et al.
Journal of comparative physiology. A, Sensory, neural, and behavioral physiology, 168(6), 647-652 (1991-06-01)
1. The effects of excitatory amino acid antagonists on synaptic transmission in the ampullae of Lorenzini of the skate Raja clavata were studied. 2. At concentrations of 10(-3) to 10(-6) M. L-glutamic acid diethylester (GDEE) and L-glutamic acid dimethylester (GDME)
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