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Merck
CN

486825

L-Leucine-5,5,5-d3

99 atom % D

Synonym(s):

SILAC Amino Acid

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About This Item

Linear Formula:
CH3CH(CD3)CH2CH(NH2)CO2H
CAS Number:
87828-86-2
Molecular Weight:
134.19
NACRES:
NA.12
PubChem Substance ID:
24872215
UNSPSC Code:
12352209
MDL number:
MFCD00144628

Key Documents

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Product Name

L-Leucine-5,5,5-d3, 99 atom % D

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1/i1D3/t4?,5-

SMILES string

[2H]C([2H])([2H])C(C)C[C@H](N)C(O)=O

InChI key

ROHFNLRQFUQHCH-LONBSJBQSA-N

isotopic purity

99 atom % D

assay

99% (CP)

form

solid

optical activity

[α]25/D +14.5°, c = 2 in 5 M HCl

technique(s)

protein expression: suitable

mp

>300 °C (lit.)

mass shift

M+3

Quality Level

200

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Application

L-leucine-5,5,5-d3 is used in the quantitative determination of proteins using mass spectrometry and also used in the synthesis of (2S,4R)-(5,5,5-d3)leucine via stereospecific manner.
Used in the methodology of stable isotope tagging of epitopes (SITE) for identification of virus-induced peptides in vaccine development.

General description

L-leucine-5,5,5-d3 is an isotopic analogue of L-leucine.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

美国出口管控产品
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Certificates of Analysis (COA)

Lot/Batch Number
MBBF0881
MBBD9620
MBBD6019
MBBD5449
MBBD4316

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Gerald W Becker
Briefings in functional genomics & proteomics, 7(5), 371-382 (2008-12-25)
Straightforward methods for the introduction of stable isotopes into proteins with subsequent isolation and purification of the proteins will greatly aid the field of quantitative proteomics. Proteins containing amino acids with one or more of the stable isotopes of deuterium
Hugo D Meiring et al.
Molecular & cellular proteomics : MCP, 5(5), 902-913 (2006-01-25)
Identification of peptides presented in major histocompatibility complex (MHC) class I molecules after viral infection is of strategic importance for vaccine development. Until recently, mass spectrometric identification of virus-induced peptides was based on comparative analysis of peptide pools isolated from

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