48640
Ethyl gallate
antioxidant, ≥96.0% (HPLC)
Synonym(s):
3,4,5-Trihydroxybenzoic acid ethyl ester, Ethyl 3,4,5-trihydroxybenzoate, Progallin A
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About This Item
Linear Formula:
3,4,5-(OH)3C6H2COOC2H5
CAS Number:
Molecular Weight:
198.17
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
212-608-5
Beilstein/REAXYS Number:
2116014
MDL number:
Product Name
Ethyl gallate, antioxidant, ≥96.0% (HPLC)
InChI key
VFPFQHQNJCMNBZ-UHFFFAOYSA-N
InChI
1S/C9H10O5/c1-2-14-9(13)5-3-6(10)8(12)7(11)4-5/h3-4,10-12H,2H2,1H3
SMILES string
CCOC(=O)c1cc(O)c(O)c(O)c1
assay
≥96.0% (HPLC)
form
solid
functional group
ester
Quality Level
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Application
Ethyl gallate is utilized as a reactant in thesynthesis of quinoxalines via sustainable green chemistry process.
- Wound healing enhancement: Ethyl gallate, isolated from Caesalpinia mimosoides, demonstrated significant effects in promoting cutaneous wound healing. This discovery supports its potential application in therapeutic treatments for skin regeneration (Bhat et al., 2023).
- Pharmacokinetics in ethanolic extracts: A study involving ethanolic extracts of Terminalia chebula, which include ethyl gallate, detailed the pharmacokinetics of these active compounds in rats, providing critical data for pharmaceutical applications and drug development processes (Yao et al., 2023).
- Ethnopharmacology research: Research on Rubus idaeus, a source of ethyl gallate, covered extensive ethnobotany, phytochemical, and pharmacological aspects, offering insights into traditional uses and modern applications, highlighting its potential in ethnopharmacology (Tao et al., 2023).
- Dermal applications: Ethyl gallate was used in a topical ointment from Caesalpinia mimosoides to attenuate dermal wounds. This application underscores its effectiveness in skin care and treatment strategies (Bhat et al., 2022).
- Neuroprotective effects: The Jingchuan tablet, which includes ethyl gallate, has been studied for its therapeutic role in treating ischaemic cerebral stroke, focusing on the HIF-1α/EPO/VEGFA signalling pathway. This research outlines its importance in neuroprotective strategies (Zhang et al., 2022).
General description
Ethyl gallate is the ethyl ester of gallic acid that belongs to a class of phenolic compound. It is an aromatic compound that is commonly used as a starting material during the synthesis of ellagic acid via transesterification reactions.
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Facile synthesis of new quinoxalines from ethyl gallate by green chemistry protocol
Rafaely L N, et al.
Tetrahedron Letters, 58, 825-828 (2017)
Dan-Dan Tian et al.
Drug metabolism and disposition: the biological fate of chemicals, 46(5), 552-560 (2018-02-23)
Green tea (Camellia sinensis) is a popular beverage worldwide, raising concern for adverse interactions when co-consumed with conventional drugs. Like many botanical natural products, green tea contains numerous polyphenolic constituents that undergo extensive glucuronidation. As such, the UDP-glucuronosyltransferases (UGTs), particularly
J Wu et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 76(4), 661-664 (1999-04-01)
The peroxidation of human erythrocytes induced by peroxyl radical initiator and its inhibition by several gallate esters (e.g., propyl, methyl, ethyl) and Trolox (a more polar analogue of vitamin E) have been studied. The antioxidant activity was determined on erythrocytes
C Cueva et al.
Letters in applied microbiology, 54(6), 557-563 (2012-03-28)
To investigate the effect of seven wine phenolic compounds and six oenological phenolic extracts on the growth of pathogenic bacteria associated with respiratory diseases (Pseudomonas aeruginosa, Staphylococcus aureus, Moraxella catarrhalis, Enterococcus faecalis, Streptococcus sp Group F, Streptococcus agalactiae and Streptococcus
Steven N Mink et al.
Journal of applied physiology (Bethesda, Md. : 1985), 110(2), 359-374 (2010-11-13)
Although hydrogen peroxide (H2O2) is a well-described reactive oxygen species that is known for its cytotoxic effects and associated tissue injury, H2O2 has recently been established as an important signaling molecule. We previously demonstrated that lysozyme (Lzm-S), a mediator of
Protocols
HPLC Analysis of Polyphenols in Nero d'Avola Red Wine on Discovery® HS C18 (UV 280 nm)
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