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Sigma-Aldrich

Sodium L-lactate-13C3 solution

45-55 % (w/w) in H2O, ≥99 atom % 13C, ≥98% (CP), ≥98% (Chiral purity, HPLC)

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Synonym(s):
L-Lactic acid-13C3 sodium salt solution
Linear Formula:
13CH313CH(OH)13CO2Na
CAS Number:
201595-71-3
Molecular Weight:
115.04
MDL number:
MFCD00084069
UNSPSC Code:
12352200
PubChem Substance ID:
24872149
NACRES:
NA.12

description

Packaged as gram of solution 45-55%(w/w)

Quality Level

200

isotopic purity

≥99 atom % 13C

Assay

≥98% (CP)
≥98% (Chiral purity, HPLC)

concentration

45-55 % (w/w) in H2O

technique(s)

mass spectrometry (MS): suitable

mp

163-165 °C (lit.)

mass shift

M+3

storage temp.

−20°C

SMILES string

[Na+].[13CH3][13C@H](O)[13C]([O-])=O

InChI

1S/C3H6O3.Na/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);/q;+1/p-1/t2-;/m0./s1/i1+1,2+1,3+1;

InChI key

NGSFWBMYFKHRBD-USULVYIHSA-M

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General description

Sodium L-lactate-13C3 is an isotopic analogue of sodium L-lactate.

Application

Sodium L-lactate-13C3 can be used an internal standard for the quantitative determination of blood lactate and pyruvate using filter-paper dried blood spots followed by LC-MS/MS. It can also be used to study the metabolism of NAD redox metabolism or lactate levels, which may be help to develop novel immunotherapies in cancer and therapeutic immunosuppression.
Sodium L-lactate-13C3 has been used as an internal standard in the quantification of metabolites in murine tumor interstitial fluid using the LC/MS technique.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jin-Wen Song et al.
Cell metabolism, 32(2), 188-202 (2020-07-02)
The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented threat to global public health. Herein, we utilized a combination of targeted and untargeted tandem mass spectrometry to analyze the plasma lipidome and metabolome in mild, moderate, and severe COVID-19 patients
Isolation and Quantification of Metabolite Levels in Murine Tumor Interstitial Fluid by LC/MS
Sullivan MR, et al.
Bio-protocol, 9, e3427-e3427 (2019)
M Testa et al.
Journal of ocular pharmacology, 3(3), 211-225 (1987-01-01)
Substances derived from biotransformation of non-steroid antiinflammatory drugs (NSAID) produced by patients responsive to the biological liquid oxidant activity (BLOA) test, have been shown to have anticataract activity. They are all aromatic alcohols with physico-chemical properties similar to benzyl alcohols
Chih-Kuang Chuang et al.
Journal of chromatography. A, 1216(51), 8947-8952 (2009-11-17)
Lactic acidemia is commonly associated with severe diseases in pediatric patients. Quantitation of blood lactate and pyruvate is important for the diagnosis and clinical management. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method using dried blood spots (DBS) was developed and
Minfeng Ying et al.
Redox biology, 46, 102065-102065 (2021-07-23)
Although glucose, through pentose phosphate pathway (PPP), is the main source to generate NADPH, solid tumors are often deprived of glucose, hence alternative metabolic pathways to maintain NADPH homeostasis in cancer cells are required. Here, we report that lactate and

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