485896
L-Asparagine-(amide-15N) monohydrate
98 atom % 15N
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Linear Formula:
H215NCOCH2CH(NH2)CO2H · H2O
CAS Number:
Molecular Weight:
151.13
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.12
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isotopic purity
98 atom % 15N
Quality Level
form
solid
optical activity
[α]20/D +31.5°, c = 1 in 1 M HCl
mp
233-235 °C (lit.)
mass shift
M+1
SMILES string
O.N[C@@H](CC([15NH2])=O)C(O)=O
InChI
1S/C4H8N2O3.H2O/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H2,6,7)(H,8,9);1H2/t2-;/m0./s1/i6+1;
InChI key
RBMGJIZCEWRQES-UEFLAVRISA-N
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Packaging
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WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Jun Wu et al.
Nature cell biology, 23(1), 75-86 (2021-01-10)
Nutrient availability is central for T-cell functions and immune responses. Here we report that CD8+ T-cell activation and anti-tumour responses are strongly potentiated by the non-essential amino acid Asn. Increased Asn levels enhance CD8+ T-cell activation and effector functions against
Longfei Deng et al.
Nature communications, 11(1), 1755-1755 (2020-04-11)
Asparagine synthetase (ASNS) catalyses the ATP-dependent conversion of aspartate to asparagine. However, both the regulation and biological functions of asparagine in tumour cells remain largely unknown. Here, we report that p53 suppresses asparagine synthesis through the transcriptional downregulation of ASNS
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