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481181

Sigma-Aldrich

Silver(I) sulfadiazine

98%

Synonym(s):

Silver sulfadiazine, Sulfadiazine silver

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About This Item

Empirical Formula (Hill Notation):
C10H9AgN4O2S
CAS Number:
22199-08-2
Molecular Weight:
357.14
EC Number:
244-834-5
MDL number:
MFCD00072101
UNSPSC Code:
12352302
PubChem Substance ID:
24871745
NACRES:
NA.23
Assay:
98%
form:
powder

Quality Level

100

Assay

98%

form

powder

mp

285 °C (dec.) (lit.)

SMILES string

Nc1ccc(cc1)S(=O)(=O)N([Ag])c2ncccn2

InChI

1S/C10H9N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1

InChI key

UEJSSZHHYBHCEL-UHFFFAOYSA-N

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Application

Silver(I) sulfadiazine (AgSD) is popularly used for treating second-degree burn wounds as it acts as an antimicrobial agent and prevents infections. Silver sulfadiazine-impregnated polyurethane (PU) foam, chitosan/chondroitin sulfate films may be used for wound dressing.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF3160V
WXBD9153V
MKCS0591
MKCN0160
MKCJ6788

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How can Silver sulfadiazine, Product 481181, be dissolved?

    Although Sigma-Aldrich does not test the solubility of the silver salt, per the chemicals encyclopedia published by the Royal Society of Chemistry (13th ed.), sulfadiazine is sparingly soluble in water (13mg/100mL at pH 5.5 and 200mg/100mL at pH 7.5), alcohol, and acetone and freely soluble in dilute mineral acids , solutions of potassium and sodium hydroxide, and aqueous ammonium hydroxide.

  4. What can Silver sulfadiazine, Product 481181, be used for?

    Although silver sulfadiazine has some potential medical applications, including antibacterial actions and treatment of second and third-degree burns, this product as it is sold is not intended for use with or on humans. Product 481181 is meant for use in research and development purposes only.  

  5. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  6. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Natural and synthetic polymers for wounds and burns dressing.
Mogosanu GD and Grumezescu AM
International Journal of Pharmaceutics, 463(2), 127-136 (2014)
Luísiane de Ávila Santana et al.
Ultrasonics, 53(4), 870-879 (2013-01-09)
The immunological mechanisms that are triggered by Low-Intensity Pulsed Ultrasound (LIPUS) in wound healing are unknown. In the present study, experimental groups were used to assess the treatment of chronic venous ulcers with 30mW/cm(2) SATA peripheral LIPUS three times per
Annette Downe
British journal of community nursing, Suppl, S32-S32 (2013-05-21)
This product focus seeks to give an overview of the management of wound bioburden in relation to the use of antimicrobial dressings, according to recent guidelines and best practice statements. Identification of critical colonisation/localised infection and the role of biofilms
Silver as biocides in burn and wound dressings and bacterial resistance to silver compounds.
Silver S, et al.
Journal of Industrial Microbiology, 33(7), 627-634 (2006)
Daniel J Ostlie et al.
Journal of pediatric surgery, 47(6), 1204-1207 (2012-06-19)
The 2 most commonly used topical agents for partial thickness burns are silver sulfadiazine (SSD) and collagenase ointment (CO). Silver sulfadiazine holds antibacterial properties, and eschar separation occurs naturally. Collagenase ointment is an enzyme that cleaves denatured collagen facilitating separation
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