All Photos(1)
Synonym(s):
4-(4-Morpholinyl)pyridine, 4-(4-Pyridinyl)morpholine, N-(4-Pyridinyl)morpholine
Empirical Formula (Hill Notation):
C9H12N2O
CAS Number:
Molecular Weight:
164.20
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
97%
form
solid
mp
102-108 °C (lit.)
SMILES string
C1CN(CCO1)c2ccncc2
InChI
1S/C9H12N2O/c1-3-10-4-2-9(1)11-5-7-12-8-6-11/h1-4H,5-8H2
InChI key
QJWQYVJVCXMTJP-UHFFFAOYSA-N
Related Categories
General description
4-Morpholinopyridine (MORP) can be synthesized by the reduction of its 1-oxide. It undergoes morpholine ring contraction on reacting with trimethylsilylmethyllithium (TMSCH2Li).
Application
4-Morpholinopyridine may be used in the synthesis of 1-alkyl-4-morpholinopyridinium halides. It may also be used as a secondary enhancer to improve the chemiluminescence of horseradish peroxidase (HRP) catalyzed oxidation of luminol.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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1-Alkyl-4-dialkylaminopyridinium halides as phase-transfer catalysts in dichlorocarbene reactions.
Kupetis GK, et al.
Monatshefte fur Chemie / Chemical Monthly, 133(3), 313-321 (2002)
Concomitant morpholine ring contraction and pyridine lithiation in 4-morpholinopyridine: straightforward access to N-pyridyl oxazolidines.
Gros PC, et al.
Tetrahedron Letters, 49(32), 4717-4719 (2008)
Oleg L Bodulev et al.
Analytical and bioanalytical chemistry, 412(21), 5105-5111 (2020-01-29)
Nowadays, considerable efforts are focused on advancing DNA detection methods, which are extremely important in clinical diagnostics, pathogen determination, gene therapy, and forensic analysis. A one-pot sensitive microplate-based chemiluminescent assay coupled with catalytic hairpin assembly (CHA) amplification for detection of
Xiaoqi Tao et al.
Luminescence : the journal of biological and chemical luminescence, 29(4), 301-306 (2013-06-21)
In this study, a high sensitivity chemiluminescence enzyme immunoassay (CLEIA) based on novel enhancers was developed. Under optimal conditions, we developed an enhanced chemiluminescence reaction (ECR) catalyzed by horseradish peroxidase (HRP-C) in the presence of 3-(10'-phenothiazinyl) propane-1-sulfonate (SPTZ) and 4-morpholinopyridine
Anton M Solovjev et al.
Talanta, 215, 120895-120895 (2020-04-22)
Sensitive microplate-based chemiluminescent assay coupled with isothermal circular strand-displacement polymerization reaction (ICSDPR) for DNA detection was developed. The assay sensitivity was improved using a triple amplification strategy based on employment of ICSDPR, streptavidin-polyperoxidase conjugate and an enhanced chemiluminescent reaction. To
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