All Photos(5)

Documents

47672

Fmoc-Asn(Trt)-OH

Name: Fmoc-Asn(Trt)-OH
Brand: ALDRICH

≥97.0%, for peptide synthesis

Synonym(s):

N_α-(9-Fluorenylmethoxycarbonyl)-N_γ-trityl-L-asparagine, N_α-Fmoc-N_γ-trityl-L-asparagine

Sign Into View Organizational & Contract Pricing

All Photos(5)

About This Item

Empirical Formula (Hill Notation):

C₃₈H₃₂N₂O₅

CAS Number:

132388-59-1

Molecular Weight:

596.67

Beilstein:

4343823

MDL number:

MFCD00077049

UNSPSC Code:

12352209

eCl@ss:

32160406

PubChem Substance ID:

57651076

NACRES:

NA.26

product name

Fmoc-Asn(Trt)-OH, ≥97.0%

Quality Level

100

Assay

≥97.0%

form

powder

optical activity

[α]20/D −15.0±1°, c = 1% in methanol

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

mp

201-204 °C (lit.)

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

2-8°C

SMILES string

OC(=O)[C@H](CC(=O)NC(c1ccccc1)(c2ccccc2)c3ccccc3)NC(=O)OCC4c5ccccc5-c6ccccc46

InChI

1S/C38H32N2O5/c41-35(40-38(26-14-4-1-5-15-26,27-16-6-2-7-17-27)28-18-8-3-9-19-28)24-34(36(42)43)39-37(44)45-25-33-31-22-12-10-20-29(31)30-21-11-13-23-32(30)33/h1-23,33-34H,24-25H2,(H,39,44)(H,40,41)(H,42,43)/t34-/m0/s1

InChI key

KJYAFJQCGPUXJY-UMSFTDKQSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

Amino Acids, Resins & Reagents for Peptide Synthesis

Exclusive Savings

General description

Fmoc-Asn(Trt)-OH has good solubility properties in most organic solvents, and its use has been shown to result in significantly purer peptides than other derivatives used for the introduction of Asn [1, 2]. Coupling can be performed by standard procedures. The trityl group is normally removed by 95% TFA in 1-3 hours, with no alkylation of Trp residues. When Asn(Trt) is the N-terminal residue, the reaction time may need to be extended to ensure complete deprotection [3].

Application

Fmoc-Asn(Trt)-OH has been used to synthesize peptides on cellulose membrane by SPOT method

Pictograms

GHS09

Hazard Statements

H411

Hazard Classifications

Aquatic Chronic 2

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Mapping of domain-mediated protein-protein interaction by SPOT peptide assay.

Xiaoyi Mao et al.

STAR protocols, 2(2), 100503-100503 (2021-05-18)

Identification of peptides mediating protein-protein interaction (PPI) is crucial for understanding the function of interlinked proteins in cellular processes and amino acid-associated diseases. Traditional PPI assays are laborious, involving the generation of many truncated proteins. SPOT peptide assay allows high-throughput

Chemical synthesis of a polypeptide backbone derived from the primary sequence of the cancer protein NY-ESO-1 enabled by kinetically controlled ligation and pseudoprolines.

Paul W R Harris et al.

Biopolymers, 104(2), 116-127 (2015-02-07)

The cancer protein NY-ESO-1 has been shown to be one of the most promising vaccine candidates although little is known about its cellular function. Using a chemical protein strategy, the 180 amino acid polypeptide, tagged with an arginine solubilizing tail

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service