467804
Hydroxylamine solution
50 wt. % in H2O, 99.999%
Synonym(s):
HDA
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About This Item
Linear Formula:
NH2OH
CAS Number:
Molecular Weight:
33.03
EC Number:
MDL number:
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.22
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Assay
99.999%
concentration
50 wt. % in H2O
bp
107 °C
density
1.078 g/mL at 25 °C
SMILES string
NO
InChI
1S/H3NO/c1-2/h2H,1H2
InChI key
AVXURJPOCDRRFD-UHFFFAOYSA-N
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General description
Hydroxylamine solution is widely used as a reducing agent and antioxidant in organic synthesis, polymer industry and water treatment.[1]
Application
Hydroxylamine solution (NH2OH) can be used as a reactant for the preparation of:
- Primary amides from aldehydes catalyzed by an arene–ruthenium(II) complex.[2]
- Hydroxyaminoguanidines and carboxamide derivatives of ofloxacin for biological studies.[3][4]
- Fe3O4/Au (GoldMag) nanoparticles for antibody immobilization.[5]
Reactant for preparation of:
- Prodrug for cardiovascular agent Nω-hydroxy-L-arginine (NOHA, nitric oxide precursor)
- Hydroxyaminoguanidines as anti-cancer agents
- Nonsteroidal 2,3-dihydroquinoline glucocorticoid receptor agonists with reduced phosphoenolpyruvate caboxykinase (PEPCK) transactivation
- Carboxamide derivatives of ofloxacin with improved antimicrobial properties
- Analogues of coumarin based TNF-α converting enzyme (TACE) inhibitors
- HIV integrase inhibitors
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Desen. Expl. 4 - Eye Dam. 1 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 3
Target Organs
Blood, Respiratory system
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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N-Hydroxy-N′-aminoguanidines as anti-cancer lead molecule: QSAR, synthesis and biological evaluation
Basu A, et al.
Bioorganic & Medicinal Chemistry Letters, 21(11), 3324-3328 (2011)
Synthesis, characterization and biological activity of a series of carboxamide derivatives of ofloxacin
Arayne MS, et al.
Archives of Pharmacal Research, 33(12), 1901-1909 (2010)
Using hydroxylamine as a reducer to prepare N-doped graphene hydrogels used in high-performance energy storage
Chang, Yunzhen and Han, et al.
Journal of Power Sources, 238, 492-500 (2013)
The synthesis of GoldMag nano-particles and their application for antibody immobilization
Cui Y, et al.
Biomedical Microdevices, 7(2), 153-156 (2005)
Ruthenium-catalyzed one-pot synthesis of primary amides from aldehydes in water
Garcia-Alvarez R, et al.
Royal Society of Chemistry Advances, 3(17), 5889-5894 (2013)
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