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Sigma-Aldrich

Brij® S 100

average Mn ~4,670

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Synonym(s):
Polyoxyethylene (100) stearyl ether
Linear Formula:
C18H37(OCH2CH2)nOH, n~100
CAS Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23

mol wt

average Mn ~4,670

Quality Level

mp

51-54 °C (lit.)

hydroxyl value

13‑25 mg KOH/g

solubility

propylene glycol and xylene: insoluble

density

1.1 g/mL at 25 °C (lit.)

HLB

18

InChI

1S/C20H41O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-22-20-18-21/h2-20H2,1H3

InChI key

PSEGVHKUPXNGGJ-UHFFFAOYSA-N

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Application

Brij® S 100 may be used:
  • as a non-ionic surfactant to study its interactions with luminol electrochemiluminescence for bioanalysis
  • as a carrier material to study the formulation of nimodipine, fenofibrate, and o-vanillin using the particles from gas-saturated solution (PGSS) process
  • as a hydrophilic surfactant in the casting solution to prepare an asymmetric flat sheet nanofiltration membranes and to study its effects on the hydrophilic property of the poly(ethersulfone) (PES) nanofiltration membranes

Legal Information

Brij is a registered trademark of Croda International PLC

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Formulation of nimodipine, fenofibrate, and o-vanillin with Brij S100 and PEG 4000 using the PGSS process
Kravanja G, et al.
Journal of Supercritical Fluids, 135, 245-253 (2018)
Lingyan Song et al.
Journal of colloid and interface science, 328(2), 374-384 (2008-10-17)
Patternable nanoporous silica thin films with pore sizes on multiple length scales are fabricated using preformed block copolymer/homopolymer blend films as templates. Previous work by Tirumala et al. [V.R. Tirumala, R.A. Pai, S. Agarwal, J.J. Testa, G. Bhatnagar, A.H. Romang
S Rahima Benhabbour et al.
Journal of controlled release : official journal of the Controlled Release Society, 158(1), 63-71 (2011-11-01)
Lipid-based oil-filled nanoparticles (NPs) with a high concentration of surface-chelated nickel (Ni-NPs) were successfully prepared using a Brij 78-NTA-Ni conjugate synthesized with Brij 78 (Polyoxyethylene (20) stearyl ether) and nitrilotriacetic acid (NTA). The facile incorporation of the Brij 78-NTA-Ni conjugate
J Q Zhang et al.
Drug delivery, 14(6), 381-387 (2007-08-19)
The study describes the development of stealth solid lipid nanoparticles (SLNs) as colloidal carriers for silibinin, a drug with very low solubility. Stealth SLNs were constituted mainly of bioacceptable and biodegradable lipids, such as stearic acid and surfactant Brij 78
S O Williams et al.
Drug development and industrial pharmacy, 26(1), 71-77 (2000-04-01)
The purpose of this study was to scale up an oil/water (o/w) cream formulation containing 40% diethylene glycol monoethyl ether (DGME), developed via 300-g laboratory batches in a 2(5-2) fractional factorial design, to 7-kg batch sizes in a Brogli-10 homogenizer.

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