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443328

Sigma-Aldrich

N-Isopropyl-N-methyl-tert-butylamine

98%

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Linear Formula:
(CH3)3CN(CH3)CH(CH3)2
CAS Number:
85523-00-8
Molecular Weight:
129.24
MDL number:
MFCD00274225
UNSPSC Code:
12352100
PubChem Substance ID:
24868058
NACRES:
NA.22

Quality Level

100

Assay

98%

form

liquid

refractive index

n20/D 1.419 (lit.)

bp

127 °C (lit.)

density

0.767 g/mL at 25 °C (lit.)

SMILES string

CC(C)N(C)C(C)(C)C

InChI

1S/C8H19N/c1-7(2)9(6)8(3,4)5/h7H,1-6H3

InChI key

WYLLBTPEHIVUKV-UHFFFAOYSA-N

Related Categories

General description

N-Isopropyl-N-methyl-tert-butylamine is a tertiary amine. BH3.THF stabilized by N-isopropyl N-methyl tert-butylamine is useful for the carbonyl reductions.

Application

N-Isopropyl-N-methyl-tert-butylamine may be used to stabilize the borane-THF solutions. It may also be used for the synthesis of rotaxane, via Sonogashira coupling.

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Statements

H225,H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Process Development of a Potent Glucosylceramide Synthase Inhibitor.
Cooper CGF, et al.
Organic Process Research & Development, 16(5), 1090-1097 (2011)
Xiaogen Huang et al.
Organic letters, 9(9), 1793-1795 (2007-04-03)
[reaction: see text] The enantioselective borane reduction of O-benzyloxime ethers to primary amines was studied under catalytic conditions using the spiroborate esters 5-10 derived from nonracemic 1,2-amino alcohols and ethylene glycol. Effective catalytic conditions were achieved using only 10% of
Borane-THF: New Solutions with Improved Thermal Properties and Stability.
Potyen M, et al.
Organic Process Research & Development, 11(2), 210-214 (2007)
Dominic Thibeault et al.
Molecules (Basel, Switzerland), 15(5), 3709-3730 (2010-07-27)
The number of synthetic methods enabling the preparation of ammonium-based rotaxanes has increased very rapidly in the past ten years. The challenge in the synthesis of rotaxanes results from the rather weak interactions between the ammonium-containing rod and the crown
Jeffrey A Crank et al.
Journal of the American Society for Mass Spectrometry, 20(10), 1790-1800 (2009-08-12)
Second generation ionic liquid matrices are developed, examined, and tested. They have shown a wide mass detection range (<1000 Da to >270,000 Da) for proteins and peptides with greater S/N ratios than solid matrices. These ionic liquid matrices also exhibit

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