428949
4-Methyl-3-nitrobenzoyl chloride
99%
Synonym(s):
3-Nitro-p-toluoyl chloride
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Linear Formula:
CH3C6H3(NO2)COCl
CAS Number:
Molecular Weight:
199.59
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Assay
99%
form
liquid
refractive index
n20/D 1.581 (lit.)
bp
185 °C/36 mmHg (lit.)
mp
20-21 °C (lit.)
density
1.37 g/mL at 25 °C (lit.)
SMILES string
Cc1ccc(cc1[N+]([O-])=O)C(Cl)=O
InChI
1S/C8H6ClNO3/c1-5-2-3-6(8(9)11)4-7(5)10(12)13/h2-4H,1H3
InChI key
DXMHBBURYDVYAI-UHFFFAOYSA-N
General description
4-Methyl-3-nitrobenzoyl chloride is a benzoyl chloride derivative. It has been reported to be synthesized from 4-methyl-3-nitrobenzoic acid.
Application
4-Methyl-3-nitrobenzoyl chloride was used in the synthesis of 4-amino-1,5-naphthalenedisulphonate acid monosodium salt, an intermediate employed in the synthesis of modified suramin molecule.
It may be used in the synthesis of the following:
It may be used in the synthesis of the following:
- benzophenone derivative
- substituted 3-amino-4-methyl-N-phenylbenzamide
- retroamide
- 4-methyl-3-nitro-N-phenylbenzamide
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
WGK
WGK 3
Flash Point(F)
235.4 °F
Flash Point(C)
113 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
新产品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Shuxin Li et al.
Bioorganic & medicinal chemistry letters, 22(16), 5279-5282 (2012-07-14)
A series of acrylamide analogues were designed and synthesized from Imatinib and Nilotinib as novel BCR-ABL inhibitors by application of the principle of nonclassical electronic isostere. All new compounds were evaluated for their inhibitory effects on the activity of BCR-ABL
M J Ashton et al.
Journal of medicinal chemistry, 39(17), 3343-3356 (1996-08-16)
The synthesis and biological activity of a new series of benzamides and related compounds that upregulate the expression of the low-density lipoprotein (LDL) receptor in human hepatocytes (HepG2 cells) by a novel mechanism are described. The lead compound, N-[5-[(3-cyclohexylpropionyl)amino]-2-methylphenyl]-4-hydroxybe nzamide
Holly L Deak et al.
Bioorganic & medicinal chemistry letters, 18(3), 1172-1176 (2007-12-18)
N-3-(Phenylcarbamoyl)arylpyrimidine-5-carboxamides are a novel class of selective Lck inhibitors. This series of compounds derives its selectivity from a hydrogen bond with the gatekeeper Thr316 of the enzyme. X-ray co-crystal structural data, structure-activity relationships, and the synthesis of these inhibitors are
Marie-Pierre Lézé et al.
Bioorganic & medicinal chemistry letters, 18(16), 4713-4715 (2008-07-22)
Two new series of benzonitrile derivatives on position 6 or 4 of indole ring were successfully synthesized via a Leimgruber-Batcho reaction. All the compounds were evaluated in vitro on the inhibition of aromatase (CYP19) and 17alpha-hydroxylase-C17,20-lyase (CYP17). The racemate, 4-[(1H-imidazol-1-yl)(1H-indol-4-yl)methyl]benzonitrile
Romina Croci et al.
PloS one, 9(3), e91765-e91765 (2014-03-14)
Noroviruses (NV) are +ssRNA viruses responsible for severe gastroenteritis; no effective vaccines/antivirals are currently available. We previously identified Suramin (9) as a potent inhibitor of NV-RNA dependent RNA polymerase (NV-RdRp). Despite significant in vitro activities versus several pharmacological targets, Suramin
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service