427292
1-Bromo-2-butyne
≥98%
Synonym(s):
1-(Bromomethyl)-2-methylacetylene, 2-Butyn-1-yl bromide, 2-Butynyl bromide, 4-Bromobut-2-yne
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About This Item
Linear Formula:
CH3C≡CCH2Br
CAS Number:
Molecular Weight:
132.99
Beilstein:
605306
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
≥98%
form
liquid
refractive index
n20/D 1.508 (lit.)
bp
40-41 °C/20 mmHg (lit.)
density
1.519 g/mL at 25 °C (lit.)
functional group
alkyl halide
bromo
SMILES string
CC#CCBr
InChI
1S/C4H5Br/c1-2-3-4-5/h4H2,1H3
InChI key
LNNXOEHOXSYWLD-UHFFFAOYSA-N
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General description
1-Bromo-2-butyne is a propargyl bromide derivative. It is one of the constitutional isomer of bromo butyne. Its Br-loss threshold photoionization breakdown diagram has been analyzed to derive dissociative photoionization thresholds to C4H5+ production. It participates in the preparation of linagliptin.
Application
1-Bromo-2-butyne was used in the alkylation of L-tryptophan methyl ester. It was used as a source to generate CH3CCCH2 radicals to investigate the reaction kinetics of these radicals with NO and NO2.
It may be used in the synthesis of the following:
It may be used in the synthesis of the following:
- 4-butynyloxybenzene sulfonyl chloride
- mono-propargylated diene derivative
- isopropylbut-2-ynylamine
- allenylcyclobutanol derivatives
- allyl-[4-(but-2-ynyloxy)phenyl]sulfane
- allenylindium
- alkynyl alcohols
- axially chiral teranyl compounds
Exploited in the synthesis of axially chiral teranyl compounds.
Signal Word
Warning
Hazard Statements
Hazard Classifications
Flam. Liq. 3
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
96.8 °F - closed cup
Flash Point(C)
36 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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An asymmetric [2+2+2] cycloaddition of an alpha,omega-diyne, possessing ortho-substituted aryl groups on its terminus, and a monoalkyne with oxygen functionalities gave various axially chiral teraryl compounds. The coupling proceeded with extremely high enantio- (>99.5% ee) and diastereoselectivities (dl/meso = >95/5)
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