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422827

Sigma-Aldrich

N-Methyl-4,4′-methylenedianiline

97%

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About This Item

Linear Formula:
CH3NHC6H4CH2C6H4NH2
CAS Number:
Molecular Weight:
212.29
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:

Assay

97%

form

solid

mp

61-63 °C (lit.)

SMILES string

CNc1ccc(Cc2ccc(N)cc2)cc1

InChI

1S/C14H16N2/c1-16-14-8-4-12(5-9-14)10-11-2-6-13(15)7-3-11/h2-9,16H,10,15H2,1H3

InChI key

DEAOXXGXJLMFAS-UHFFFAOYSA-N

General description

N-Methyl-4,4′-methylenedianiline (4-(4-aminobenzyl)-N-methylaniline) is a 4,4′-methylenedianiline derivative. It has been synthesized by the methylation of 4,4′-methylenedianiline using formaldehyde and characterized by 1H NMR and mass spectrometry. It has been reported to be the one of the urinary metabolites during the in vivo metabolism of 4,4′-[14C]- methylenebis(N,N-dimethyl)benzamine (reduced Michler′s ketone, RMK) in Osborne-Mendel rats.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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D J McCarthy et al.
Cancer research, 42(9), 3475-3479 (1982-09-01)
Studies on the in vivo and in vitro disposition of 4,4'-[14C]-methylenebis(N,N-dimethyl)benzamine (reduced Michler's ketone, RMK) were performed. Osborne-Mendel rats retained, after 24 hr, 78% of a p.o. dose of [14C]RMK. At 24 hr after an i.p. dose, fat, liver, and

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