412449
PAMAM dendrimer, ethylenediamine core, generation 4.0 solution
10 wt. % in methanol
Synonym(s):
Starburst Generation 4
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About This Item
Linear Formula:
[NH2(CH2)2NH2]:(G=4);dendri PAMAM(NH2)64
CAS Number:
Molecular Weight:
14214.17
MDL number:
UNSPSC Code:
12162002
NACRES:
NA.23
description
amino surface groups
Quality Level
form
solution
mol wt
generation 4.0
feature
core type ethylenediamine core (2-carbon core)
concentration
10 wt. % in methanol
no. Surface Groups
64
refractive index
n20/D 1.348
bp
64.7 °C
density
0.813 g/mL at 25 °C
storage temp.
2-8°C
Related Categories
General description
PAMAM dendrimer, ethylenediamine core, generation 4.0 solution is a poly(amidoamine) that is categorized as a class of dendritic polymers which can be prepared by a two-step interactive reaction that forms generations around the central ethylenediamine core. It consists of nitrogen and amide as functional groups that are structured in regular “branched upon branched” pattern. It is majorly used as a high capacity chelating agent.
Application
PAMAM dendrimer, ethylenediamine core, generation 4.0 solution is used as a compacting agent to bring in the conformational changes in the DNA molecule. It can be attached on the cellulose substrate that acts as a biofunctional surface for potential applications in immonoassays. It is used in MRI contrast agents and in the condensation formation of silica nanospheres.
Physical form
Contains 64 surface primary amino groups
Legal Information
Manufactured by Dendritech®, Inc.
Dendritech is a registered trademark of Dendritech, Inc.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Target Organs
Eyes
WGK
WGK 3
Flash Point(F)
closed cup
Flash Point(C)
closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
危险化学品
Certificates of Analysis (COA)
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Felipe Vidal et al.
Molecular pharmaceutics, 13(10), 3395-3403 (2016-08-25)
Polyamidoamine (PAMAM) dendrimers are hyperbranched macromolecules which have been described as one of the most promising drug nanocarrier systems. A key process to understand is their cellular internalization mechanism because of its direct influence on their intracellular distribution, association with
Rolando Alberto Rodríguez-Fonseca et al.
Colloids and surfaces. B, Biointerfaces, 177, 77-93 (2019-02-04)
Peptide epitopes have been widely used to develop synthetic vaccines and immunotherapies. However, peptide epitopes may exhibit poor absorption or immunogenicity due to their low molecular weights. Conversely, fourth-generation polyamidoamine (G4-PAMAM) dendrimers are nonimmunogenic and relatively nontoxic synthetic nanoparticles that
DNA compaction induced by a cationic polymer or surfactant impact gene expression and DNA degradation
Ainalem M, et al.
PLoS ONE, 9(3), e92692-e92692 (2014)
Marta Walczynska et al.
Toxicology mechanisms and methods, 28(6), 432-439 (2018-04-03)
Nematode Caenorhabditis elegans (C. elegans) was used to investigate the impact of silver nanoparticles (SNP), multiwalled carbon nanotubes (MWCNT), and polyamidoamine dendrimers (PAMAM) used in concentration of 1010 particle/mL. Population-based observations and gene expression analysis were employed in this study.
Marc R Knecht et al.
Langmuir : the ACS journal of surfaces and colloids, 20(11), 4728-4732 (2005-06-23)
In diatoms, silica synthesis occurs by use of complex posttranslationally modified peptides, termed silaffins, and highly complex biological polyamine structures. Silaffin peptides have lysine residues that are modified to long-chain polyamine moieties of N-methyl derivatives of polypropylenimine to drive silica
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