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412368

Sigma-Aldrich

PAMAM dendrimer

ethylenediamine core, generation 0.0 solution, 20 wt. % in methanol

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Synonym(s):
Poly(amidoamine)
Linear Formula:
NH2(CH2)2NH2]:(G=0);dendri PAMAM(NH2)4
CAS Number:
155773-72-1
Molecular Weight:
516.68
MDL number:
MFCD00192446
UNSPSC Code:
12162002
PubChem Substance ID:
24865805
NACRES:
NA.23

description

amino surface groups

Quality Level

200

form

liquid

mol wt

generation 0.0

feature

core type ethylenediamine core (2-carbon core)

concentration

20 wt. % in methanol

no. Surface Groups

4

refractive index

n20/D 1.364

bp

64.7 °C

density

0.854 g/mL at 25 °C

storage temp.

2-8°C

SMILES string

NCCNC(=O)CCN(CCN(CCC(=O)NCCN)CCC(=O)NCCN)CCC(=O)NCCN

InChI

1S/C22H48N10O4/c23-5-9-27-19(33)1-13-31(14-2-20(34)28-10-6-24)17-18-32(15-3-21(35)29-11-7-25)16-4-22(36)30-12-8-26/h1-18,23-26H2,(H,27,33)(H,28,34)(H,29,35)(H,30,36)

InChI key

SENLDUJVTGGYIH-UHFFFAOYSA-N

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General description

PAMAM dendrimer is a poly(amidoamine) that is categorized under the class of dendritic polymers, which can be prepared by a two-step reaction that forms generations around the central ethylenediamine core. It consists of nitrogen and amide as functional groups that are structured in regular branched upon branched pattern. PAMAM is majorly used as a high capacity chelating agent.

Application

PAMAM dendrimer belongs to the family of dendrimers, which can be used in biomedical and drug delivery applications.

Physical form

Contains 4 surface primary amino groups

Legal Information

Manufactured by Dendritech®, Inc.
Dendritech is a registered trademark of Dendritech, Inc.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

WGK

WGK 3

Regulatory Information

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PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionality
Majoros I, et al.
Biomacromolecules, 7(2), 572-579 (2006)
Poly (ethylene glycol)-conjugated PAMAM dendrimer for biocompatible, high-efficiency DNA delivery
Luo D, et al.
Macromolecules, 35(9), 3456-3462 (2002)
Poly (amidoamine)(PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications
Esfand R and Tomalia DA
Drug Discovery Today, 6(8), 427-436 (2001)
Dendritic chelating agents. 1. Cu (II) binding to ethylene diamine core poly (amidoamine) dendrimers in aqueous solutions
Diallo MS, et al.
Langmuir, 20(7), 2640-2651 (2004)
Dendrimer enhanced ultrafiltration. 1. Recovery of Cu (II) from aqueous solutions using PAMAM dendrimers with ethylene diamine core and terminal NH2 groups
Diallo MS, et al.
Environmental Science & Technology, 39(5), 1366-1377 (2005)
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