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Merck
CN

408166

1-(2-Pyridyl)piperazine

≥99%

Synonym(s):

2-Piperazinopyridine

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About This Item

Empirical Formula (Hill Notation):
C9H13N3
CAS Number:
34803-66-2
Molecular Weight:
163.22
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24865508
EC Number:
252-220-3
Beilstein/REAXYS Number:
140423
MDL number:
MFCD00006216

Key Documents

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Product Name

1-(2-Pyridyl)piperazine, ≥99%

InChI key

GZRKXKUVVPSREJ-UHFFFAOYSA-N

InChI

1S/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2

SMILES string

C1CN(CCN1)c2ccccn2

assay

≥99%

form

liquid

refractive index

n20/D 1.595 (lit.)

bp

120-122 °C/2 mmHg (lit.)

density

1.072 g/mL at 25 °C (lit.)

Quality Level

100

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Application

1-(2-Pyridyl)piperazine may be employed as reagent for the determination of both aliphatic and aromatic isocyanates in air by reversed-phase HPLC., It may be employed as reagent for the fluorometric determination of airborne diisocyantes.

General description

1-(2-Pyridyl)piperazine is a piperazine derivative.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

230.0 °F - closed cup

flash_point_c

110 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV7943
MKCS3791
MKCM0282
MKCG0799
MKBZ2433V

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Determination of trace atmospheric isocyanate concentrations by reversed-phase high-performance liquid chromatography using 1-(2-pyridyl) piperazine reagent.
Goldberg PA, et al.
Journal of Chromatography A, 212(1), 93-104 (1981)
Absorption and fluorescence of 1-(2-pyridyl)-piperazine and four diisocyanate derivatives in solution.
Salthammer T, et al.
Journal of Photochemistry and Photobiology A: Chemistry, 107(1), 159-164 (1997)
Determination of atmospheric isocyanate concentrations by high-performance thin-layer chromatography using 1-(2-pyridyl) piperazine reagent.
Ellwood PA, et al.
Analyst, 106(1258), 85-93 (1981)
Robert Lavieri et al.
Bioorganic & medicinal chemistry letters, 19(8), 2240-2243 (2009-03-21)
This Letter describes the synthesis and structure-activity relationships (SAR) of isoform-selective PLD inhibitors. By virtue of the installation of a 1,3,8-triazaspiro[4,5]decan-4-one privileged structure, PLD inhibitors with nanomolar potency and an unprecedented 40-fold selectivity for PLD2 over PLD1 were developed. Interestingly
Harvey Wong et al.
Drug metabolism and disposition: the biological fate of chemicals, 35(8), 1387-1392 (2007-05-15)
The pharmacokinetics and in vivo potency of 6-hydroxybuspirone (6-OH-buspirone), a major metabolite of buspirone, were investigated. The plasma clearance (47.3 +/- 3.5 ml/min/kg), volume of distribution (2.6 +/- 0.3 l/kg), and half-life (1.2 +/- 0.2 h) of 6-OH-buspirone in rats
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